Browsing School of Pharmacy and Pharmaceutical Sciences by Sponsor "Irish Cancer Society"
Now showing items 1-6 of 6
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Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.
(2018)Background: Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to ... -
MicroRNA Profiling of Exosomes
(Springer, 2017) -
miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity
(2015)Exosomes (EVs) have relevance in cell-to-cell communication carrying pro- tumorigenic factors that participate in oncogenesis and drug resistance and are proposed to have potential as self-delivery systems. Advancing ... -
Neratinib-resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4
(2017)Background: Neratinib is in Phase 3 clinical trials but, unfortunately, the development of resistance is inevitable. Here, we investigated the effects of acquired neratinib resistance on cellular phenotype and the ... -
The relevance of using 3D cell cultures, in addition to 2D monolayer cultures, when evaluating breast cancer drug sensitivity and resistance.
(2016)Solid tumours naturally grow in 3D wherein the spatial arrangement of cells affects how they interact with each other. This suggests that 3D cell culture may mimic the natural in vivo setting better than traditional ...