Browsing School of Pharmacy and Pharmaceutical Sciences by Author "Frankish, Neil"
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Bioactive Indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and rat plasma and its application to a pharmacokinetic study in dog.
Sheridan, Helen; Scalabrino, Gaia A.; Zhang, Tao; Frankish, Neil (2020)A new chemical entity, which is a chiral indane dimer, PH46A, has been developed by our research group. As a clinical candidate. PH46A has recently completed Phase I clinical studies in man. Previously, during its pre-clinical ... -
Bioactive indanes: Proof of concept study for enantioselective synthetic routes to ph46a, a new potential anti-inflammatory agent
Sheridan, Helen; Frankish, Neil (2018) -
The indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis
Sheridan, Helen; Frankish, Neil (2018)