Browsing School of Pharmacy and Pharmaceutical Sciences by Title
Now showing items 45-64 of 247
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Density Scaling in Ionic Glass-Former Controlled by Grotthuss Conduction
(2019)We present investigations of the charge transport in an ionic glass-former carvedilol dihydrogen phosphate (CP) at various T–P–V thermodynamic conditions in terms of density scaling concept. The studied material was found ... -
Design and synthesis of tubulin-binding agents, and their incorporation into novel dual-acting hybrid molecules targeting the tumour vasculature
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis involves the design and synthesis of tubulin binding agents, which aside from their anti-proliferative impact, seek to induce anti-vascular and anti-angiogenic responses on the unique vasculature derived by a ... -
Design, synthesis and biochemical evaluation of dual-acting, estrogen receptor ligand conjugates
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)Selective targeting of malignancies over healthy cells is an important goal in cancer therapies. Knowledge of environmental and biological differences between tumours and healthy tissue can present suitable targets for ... -
Design, Synthesis and biochemical evaluation of novel anthracenes, ethanoanthracenes and related compounds to target Burkitt's Lymphoma
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma occurring with high incidence in developing areas such as equatorial Africa and Papua New Guinea. Within these tropical regions of high incidence (40-50 per 10 6), ... -
Design, synthesis and evaluation of indazoles as antiproliferative agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Cancer is a leading cause of death in most countries, second only to the diseases of the circulatory system. In relation to Ireland, cancer accounted for 29.6 % of all the deaths reported in 2012. After non-melanoma skin ... -
Design, synthesis and in vitro evaluation of novel anti-cancer compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The purpose of this thesis was the design, synthesis and in vitro appraisal of a novel class of ITP/APN dual inhibitory compounds. Additionally, a class of novel biaryls, which were synthesised within the research group, ... -
Development and characterization of dapsone cocrystal prepared by scalable production methods
(American Association of Pharmaceutical Scientists ; Springer Verlag, 2018)In this study, the formation of caffeine:dapsone (CAF:DAP) cocrystals by scalable production methods, such as liquid assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed ... -
Development of inhaled formulation of modified clofazimine as an alternative to treatment of tuberculosis: Clofazimine inhaled formulation for tuberculosis
(2020)Inhalation drug delivery provides a possible useful alternative to oral drug delivery in the treatment of tuberculosis (TB). This work evaluated inclusion complexes of clofazimine (CFZ), an anti-TB drug with low aqueous ... -
Development of new pharmacological agents for the treatment of T cell diseases of the skin
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020) -
Do assorted approaches aid in estimation of uronic acids? Case studies on Tinospora sinensis polysaccharides
(2014)Polysaccharides containing uronic acids are of immense biological significance. Colorimetric methods using different chromogens have been explored for uronic acid estimation in polysaccharides but these methods counter ... -
Drug transport across the human respiratory epithelial barrier
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Drug transporters have only recently moved into the centre of attention of pulmonary drug delivery research, and of the more than 400 identified transporter proteins, only little information is available. In a first step, ... -
Economic evaluation of a collaborative model of pharmaceutical care in an Irish hospital: cost-utility analysis
(2023)Background: A complex, collaborative pharmaceutical care intervention including medication review and reconciliation demonstrated a statistically significant reduction in the prevalence of discharge medication error and ... -
Effect of 2-amino imidazoline derivatives on tumour cell-induced platelet aggregation
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Platelets play a central role in thrombosis and haemostasis. However, platelets can also aggregate in the presence of tumour cells in a phenomenon known as tumour-cell-induced-platelet-aggregation (TCIPA). During this ...