Browsing School of Pharmacy and Pharmaceutical Sciences by Title
Now showing items 600-619 of 640
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The specialist pharmacist and quality indicators of medication use in the care of people with intellectual disabilities and behaviour disorders
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)Quality Medication Use and the Population with Intellectual Disabilities and Behaviour Disorders. A Modified Delphi Technique to develop Quality Indicators and a Grounded Theory approach to information provided by people ... -
The synthesis and biochemical evaluation of novel isoquinoline derivatives
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Isoquinolines are naturally occurring alkaloids, some of which have pharmacological activity. Previous work by the research group of Dr. Mary Jane Meegan, has shown diverse classes of isoquinoline derivatives to be active ... -
The synthesis and biological evaluation of a novel class of butyrylcholinesterase inhibitors using isosorbide as a building block
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this project was to synthesise and optimise a novel class of cholinesterase inhibitors using the simple sugar, isosorbide, as a building block and to assess the inhibitory activity of these compounds in vitro. ... -
The synthesis of novel mast cell stabilisers from benzocycloalkanones
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)The purpose of this project was to design and synthesise novel classes of mast cell stabilisers from benzocycloalkanones. This thesis is introduced with an overview of the increasing prevalence of allergic conditions ... -
The use of the Caco-2 cell culture model to investigate lipid vehicle effects on lipid metabolism and drug permeation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The aim of this thesis was to assess the usefulness of the Caco-2 model for screening lipid vehicle excipient effects on intestinal lipoprotein production and secretion, with emphasis on chylomicron secretion. In addition, ... -
A theory-based exploration of the medicines management process provided to older people residing in the nursing home setting in the Republic of Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Introduction While the population is ageing globally, this does not necessarily mean that they are living healthier. The multimorbidity and polypharmacy in the older population (age> 65 years) increases their risk of ... -
Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells
(2015)Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide for a variety of engineering and bioengineering applications. TiO2NPs are frequently used as a material for orthopedic implants. However, to the best ... -
Traditional Chinese Medicine: From Aqueous Extracts to Therapeutic Formulae
(IntechOpen, 2019)Traditional Chinese medicine (TCM) is one of the most established systems of medicine in the world. The therapeutic formulae used in TCM are frequently derived from aqueous decoctions of single plants or complex multicomponent ... -
Traditional Medicinal Knowledge documented in the Schools Manuscript Collection: An insight into the medical beliefs, practices and healing plants used in 1930s Ireland.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)The National Folklore Collection (NFC) in University College Dublin holds one of the largest collections of ethnographic material globally. In 2017, the Irish Folklore Commission Collection (1935-1970), housed within the ... -
Transdermal delivery of somatostatin analogues
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The aim of this work was to develop transdermal delivery systems for the administration of two peptidic somatostatin analogues, BIM-23014 and its higher potency analogue BIM-23190. Due to its ability to suppress growth ... -
Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells
(2012)Organic cation/carnitine transporters (OCT/N) mediate uptake of positively charged molecules. Their role in lung epithelium, however, is not well understood. OCT/N expression and activity was studied in cell lines of human ... -
The treatment of obesity using magneto -mechanical effect
Obesity is a very prevalent condition that can be very often associated with the development of comorbidities, such as insulin resistance, hypertension, and hyperlipidaemia that can lead to cardiovascular and cerebrovascular ... -
Triple negative breast cancer-derived extracellular-vesicles as naturally-occuring biomarkers and therapeutic delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Background: In Ireland, breast cancer is the most commonly diagnosed cancer among women; and of the breast cancer subtypes, triple-negative breast cancers (TNBC) are the most aggressive. TNBCs account for 15%-20% of breast ... -
Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism
(2012)Peroxisome proliferator activated receptor ? (PPAR?) agonists are effective antifibrotic agents in a number of tissues. Effects of these agents on epithelial-mesenchymal transition (EMT) of primary alveolar epithelial cells ... -
Tumour microenvironment, extracellular vesicles and their effect on prostate cancer progression and docetaxel resistance
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Prostate cancer is the fourth most common cancer in Europe and the third leading cause of death in males. The standard of care as initial treatment for prostate cancer is, typically, androgen-deprivation therapy. Although ... -
Tumour vasculature targeting agents in hybrid/conjugate drugs.
(2013)Tumour vasculature targeting has been a very active area of cancer drug discovery over the last decade. Growth of solid tumours beyond a certain point requires a sufficient blood supply in order for them to develop and ... -
Twenty-first century mast cell stabilizers
(2013)Mast cell stabilizing drugs inhibit the release of allergic mediators from mast cells and are used clinically to prevent allergic reactions to common allergens. Despite the relative success of the most commonly prescribed ...