Browsing School of Pharmacy and Pharmaceutical Sciences by Title
Now showing items 189-208 of 640
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Enhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound
(2020)The main purpose of this paper was to evaluate the impact of both high- and low-Tg polymer additives on the physical stability of an amorphous drug, sildenafil (SIL). The molecular mobility of neat amorphous SIL was strongly ... -
An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations when Combined with a Permeation Enhancer
(2020)The use of nanocarriers is being researched to achieve oral peptide delivery. Insulin-associated anionic polyelectrolyte nanoparticle complexes (PECs) were formed that comprised hyaluronic acid and chitosan in an optimum ... -
Epoxy Resins: From Chemistry to Clinic
(2019)Epoxy resin systems (ERS) are commercial thermosetting products used in many diverse applications due to their outstanding performance and resistance. The global epoxy resins market accounted for $7.9 billion in 2016 and ... -
Ethnopharmacology in Ireland: an overview
(2014)The aim of this review was to extract information of the book Medicinal Plants in Folk Tradition: An Ethnobotany of Britain & Ireland published in 2004 by Allen and Hatfield, to give an overview of plants with medicinal ... -
An evaluation of ciprofloxacin pharmacokinetics in critically ill patients undergoing continuous veno-venous haemodiafiltration.
(PLoS, 2011)BACKGROUND: The study aimed to investigate the pharmacokinetics of intravenous ciprofloxacin and the adequacy of 400 mg every 12 hours in critically ill Intensive Care Unit (ICU) patients on continuous veno-venous ... -
Evidence for the Need to Evaluate More Than One Source of Extracellular Vesicles, Rather Than Single or Pooled Samples Only, When Comparing Extracellular Vesicles Separation Methods
(2021)To study and exploit extracellular vesicles (EVs) for clinical benefit as biomarkers, therapeutics, or drug delivery vehicles in diseases such as cancer, typically we need to separate them from the biofluid into which they ... -
Exaggerated increases in microglia proliferation, brain inflammatory response and sickness behaviour upon lipopolysaccharide stimulation in non-obese diabetic mice
(2016)The non-obese diabetic (NOD) mouse, an established model for autoimmune diabetes, shows an exaggerated reaction of pancreas macrophages to inflammatory stimuli. NOD mice also display anxiety when immune-stimulated. Chronic ... -
Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells
(2013)Background Triple-negative breast cancer (TNBC) accounts for 15–20% of breast cancers but is responsible for a disproportionate number of deaths. We investigated the relevance, in TNBC, of nano-sized exosomes expelled ... -
Experiences of the Medication Use Process by People with Intellectual Disabilities. What a Pharmacist Should Know!
(2021)There is a scarcity of information about the experience of people with intellectual disabilities in the medication use process. Six people with intellectual disabilities consented to be interviewed by a pharmacist to ... -
Exploring Membrane Transporters in Lung Epithelial Cells: Drug-Transporter Interaction Analyses in Different In Vitro Models
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Over the last decade, the incidence of lung-related diseases such as asthma and chronic obstructive pulmonary disease and their associated morbidity have continuously risen. A heterogeneity in treatment response to commonly ... -
Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous hemodiafiltration on different anticoagulant modalities
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Uncertainty remains concerning pharmacokinetics (PK) of antimicrobials in critically ill patients due to the scarcity of data and the variable physiology of the patient cohort. This project incorporates two distinct aims. ...