Browsing School of Pharmacy and Pharmaceutical Sciences by Title
Now showing items 149-168 of 640
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Development of inhaled formulation of modified clofazimine as an alternative to treatment of tuberculosis: Clofazimine inhaled formulation for tuberculosis
(2020)Inhalation drug delivery provides a possible useful alternative to oral drug delivery in the treatment of tuberculosis (TB). This work evaluated inclusion complexes of clofazimine (CFZ), an anti-TB drug with low aqueous ... -
Development of microemulsions and self-emulsifying systems for oral drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The main aim of the current work was to explore microemulsions (ME) and self- emulsifying lipid formulations (SELFs) comprising derivatives of capric/caprylic acids (Captex 355, Captex 200P, Capmul PG-8, Capmul MCM) as ... -
Development of new pharmacological agents for the treatment of T cell diseases of the skin
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020) -
Development of novel cyclodextrins as non-viral gene delivery vectors and assessment of differentiated cell culture models to predict in vivo gene expression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The aims of this thesis were to examine the use of differentiated cell culture systems in the in vitro assessment of non-viral gene delivery systems and to investigate the use of commercial and novel cyclodextrins as vectors ... -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
Development of the beta-lactam structure as a scaffold for biologically active compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Tamoxifen is a selective estrogen receptor modulator (SERM) with a triarylethylene structure which acts as an estrogen antagonist in the breast. This drug is used extensively as an endocrine treatment for breast cancer, ... -
Development, validation and optimisation of a vHTS protocol for identification of estrogen receptor modulators
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)The discovery of small-molecule drugs has reached a critical point in time where the number of new drugs released to market has become static regardless of the technological advances observed over the last few years. ... -
Discovery of therapies for lymphomas and leukaemia: Synthesis and antiproliferative action of novel ethanoanthracenes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Cancer is a broad class of diseases responsible for up to 9.6 million deaths worldwide in 2018, accountable for approximately every one in six deaths globally. Cancer is second only in all-cause mortality to circulatory ... -
Do assorted approaches aid in estimation of uronic acids? Case studies on Tinospora sinensis polysaccharides
(2014)Polysaccharides containing uronic acids are of immense biological significance. Colorimetric methods using different chromogens have been explored for uronic acid estimation in polysaccharides but these methods counter ... -
Do Patients Know How to Use Sublingual Glyceryl Trinitrate?
(2011)Glyceryl trinitrate is a nitrate, a potent coronary vasodilator which exerts its principal benefit by reducing venous return, which reduces left ventricular work. Vasodilation is also associated with the undesired effects ... -
Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes.
(2012)Background Hormone-refractory prostate cancer remains hindered by inevitable progression of resistance to first-line treatment with docetaxel. Recent studies suggest that phenotypic changes associated with cancer may ... -
Drug transport across the human respiratory epithelial barrier
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Drug transporters have only recently moved into the centre of attention of pulmonary drug delivery research, and of the more than 400 identified transporter proteins, only little information is available. In a first step, ... -
Dry powders for oral inhalation free of lactose carrier particles
(2014)Dry powder inhaler (DPI) products have traditionally comprised a simple formulation of micronised drug mixed with a carrier excipient, typically lactose monohydrate. The presence of the carrier is aimed at overcoming issues ... -
Dual acting nuclear receptor targeting conjugates : design, synthesis and biochemical evaluation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Breast cancer has become the second most common cancer worldwide after lung cancer, the fifth most common cause of cancer death, and the foremost cause of cancer death in women. Worldwide, breast cancer exceeds all other ... -
The DUMP Campaign
(green cross publishing, 2009-05)From an initial group of six pharmacies in 2002, now every pharmacy in the area is a part of the DUMP initiative, which urges consumers to `Dispose of Unused Medication Properly? and attempts to achieve this by ... -
Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry
(2019)Traditional culture systems for human erythropoiesis lack microenvironmental niches, spatial marrow gradients and dense cellularity rendering them incapable of effectively translating marrow physiology ex vivo. Herein, a ...