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dc.contributor.authorO'SULLIVAN, MAUREENen
dc.date.accessioned2014-12-11T10:46:57Z
dc.date.available2014-12-11T10:46:57Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationWatson JA, Bryan K, Williams R, Popov S, Vujanic G, Coulomb A, Boccon-Gibod L, Graf N, Pritchard-Jones K, O'Sullivan M, miRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema., PloS one, 8, 1, 2013, e53417en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72430
dc.descriptionPUBLISHEDen
dc.description.abstractThe current SIOP treatment protocol for Wilms’ tumor involves pre-operative chemotherapy followed by nephrectomy. Not all patients benefit equally from such chemotherapy. The aim of this study was to generate a miRNA profile of chemo resistant blastemal cells in high risk Wilms’ tumors which might serve as predictive markers of therapeutic response at the pre-treatment biopsy stage. We have shown here that unsupervised hierarchical clustering of genome-wide miRNA expression profiles can clearly separate intermediate risk tumors from high risk tumors. A total of 29 miRNAs were significantly differentially expressed between post-treatment intermediate risk and high risk groups, including miRNAs that have been previously linked to chemo resistance in other cancer types. Furthermore, 7 of these 29 miRNAs were already at the pre-treatment biopsy stage differentially expressed between cases ultimately deemed intermediate risk compared to high risk. These miRNA alterations include down-regulation in high risk cases of miR-193a.5p, miR-27a and the up-regulation of miR-483.5p, miR-628.5p, miR-590.5p, miR-302a and miR-367. The demonstration of such miRNA markers at the pre-treatment biopsy stage could permit stratification of patients to more tailored treatment regimensen
dc.description.sponsorshipThis project was funded by the Health Research Board (HRB) of Ireland, grant number: HRB MRCG 2008/1; website: http://www.hrb.ie/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripten
dc.format.extente53417en
dc.language.isoenen
dc.relation.ispartofseriesPloS oneen
dc.relation.ispartofseries8en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectWilms’ tumoren
dc.subject.lcshWilms’ tumoren
dc.titlemiRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/osullm10en
dc.identifier.rssinternalid84103en
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0053417en
dc.rights.ecaccessrightsopenAccess


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