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dc.contributor.authorDORMAN, CHARLESen
dc.date.accessioned2014-09-24T13:18:54Z
dc.date.available2014-09-24T13:18:54Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationDorman CJ, Corcoran CP, Bacterial DNA topology and infectious disease, Nucleic Acids Research, 37, 3, 2009, 672 - 678en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/71397
dc.descriptionPUBLISHEDen
dc.description.abstracthe gram-negative bacterium Escherichia coli and its close relative Salmonella enterica have made important contributions historically to our understanding of how bacteria control DNA supercoiling and of how supercoiling influences gene expression and vice versa. Now they are contributing again by providing examples where changes in DNA supercoiling affect the expression of virulence traits that are important for infectious disease. Available examples encompass both the earliest stages of pathogen-host interactions and the more intimate relationships in which the bacteria invade and proliferate within host cells. A key insight concerns the link between the physiological state of the bacterium and the activity of DNA gyrase, with downstream effects on the expression of genes with promoters that sense changes in DNA supercoiling. Thus the expression of virulence traits by a pathogen can be interpreted partly as a response to its own changing physiology. Knowledge of the molecular connections between physiology, DNA topology and gene expression offers new opportunities to fight infection.en
dc.format.extent672en
dc.format.extent678en
dc.language.isoenen
dc.relation.ispartofseriesNucleic Acids Researchen
dc.relation.ispartofseries37en
dc.relation.ispartofseries3en
dc.rightsYen
dc.subjectMicrobiologyen
dc.titleBacterial DNA topology and infectious diseaseen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/cjdormanen
dc.identifier.rssinternalid53976en
dc.identifier.doihttp://dx.doi.org/10.1093/nar/gkn996en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.orcid_id0000-0002-6018-9170en


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