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The P300 as a marker of waning attention and error propensity
(2007)Action errors can occur when routine responses are triggered inappropriately by familiar cues. Here, EEG was recorded as volunteers performed a ?go/no-go? task of long duration that occasionally and unexpectedly required ... -
P53 CODON 72 POLYMORPHISM AND HUMAN PAPILLOMAVIRUS ASSOCIATED SKIN CANCER
(2001)BACKGROUND/AIMS-NON-MELANOMA SKIN CANCERS FREQUENTLY HARBOUR MULTIPLE HUMAN PAPILLOMAVIRUS (HPV) TYPES. A RECENT REPORT SUGGESTS THAT ALPOLYMORPHISM OF THE P53 TUMOUR SUPPRESSOR GENE THAT RESULTS IN THE SUBSTITUTION OF A ... -
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
(2008)The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose ... -
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
(2019)SESTRINs (SESN1-3) are proteins encoded by an evolutionarily conserved gene family that plays an important role in the regulation of cell viability and metabolism in response to stress. Many of the effects of SESTRINs are ... -
Packing a punch: Understanding how flavours are produced in lager fermentations
(2021)Beer is one of the most popular beverages in the world and it has an irreplaceable place in culture. Although invented later than ale, lager beers dominate the current market. Many factors relating to the appearance (colour, ... -
Packing soft spheres: experimental demonstrations with hydrogels
(2023)We describe a number of different experimental set-ups that use hydrogel spheres to demonstrate dense packings of deformable spheres in various geometries. The arrangements are similar to those of bubbles in foams, ... -
Paging through history: Parchment as a reservoir of ancient DNA for next generation sequencing
(2015)Parchment represents an invaluable cultural reservoir. Retrieving an additional layer of information from these abundant, dated livestock-skins via the use of ancient DNA (aDNA) sequencing has been mooted by a number of ... -
Pain in the Past and Pleasure in the Future: The Development of Past Future Preferences for Hedonic Goods
(2020)It seems self‐evident that people prefer painful experiences to be in the past and pleasurable experiences to lie in the future. Indeed, it has been claimed that, for hedonic goods, this preference is absolute (Sullivan, ... -
Paired associative transcranial alternating current stimulation increases the excitability of corticospinal projections in humans
(2015)Many types of non-invasive brain stimulation alter corticospinal excitability (CSE). Paired associative stimulation (PAS) has attracted particular attention as its effects ostensibly adhere to Hebbian principles of neural ... -
Palladium bis(phosphinite) 'PCP'-pincer complexes and their application as catalysts in the Suzuki Reaction
(2000)Palladium complexes of inexpensive, easily synthesised bis(phosphinite) `PCP ?-pincer ligands show good activity in the Suzuki coupling of deactivated and sterically hindered aryl bromides -
Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives
(BMJ, 2011)Background: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition. Optimal management requires a palliative approach from diagnosis with emphasis on patient autonomy, dignity and ... -
Palliative care in the era of novel oncological interventions: needs some "tweaking"
(2022)Cancer treatment has evolved enormously over the last 20 years, with developments in surgery, radiotherapy, chemo- therapy, targeted therapy, and immunotherapy. As a result, many cancer patients have improved outcomes ... -
PALM: A Personal Activity Location Model of Exposure to Air Pollution
(Irish Epa, 2015) -
Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS)
(2016)Clinically relevant postoperative pancreatic fistula (grades B and C of the ISGPS definition) remains the most troublesome complication after pancreatoduodenectomy. The approach to management of the pancreatic remnant via ... -
Panel-Based population next-generation sequencing for inherited retinal degenerations
(2016)Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of genes and mutations implicated in these ... -
PANTON-VALENTINE LEUKOCIDIN-POSITIVE STAPHYLOCOCCUS AUREUS IN IRELAND 2002-2011: TWENTY-ONE CLONES, FREQUENT IMPORTATION OF CLONES, TEMPORAL SHIFTS OF PREDOMINANT METHICILLIN-RESISTANT S. AUREUS AND INCREASING MULTIRESISTANCE
(2014)There has been a worldwide increase in community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections. CA-MRSA isolates commonly produce the Panton-Valentine leukocidin toxin encoded by the pvl ...