Browsing Microbiology by Title
Now showing items 310-318 of 318
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Understanding the Role of Host Factors in the Modulation of Virulence Factors of Staphylococcus aureus.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023)Staphylococcus aureus is adept at colonising and infecting the human host. Host factors are known to influence pathogen physiology and this thesis aimed to examine the effects of human bile and human plasmin on S. aureus. ... -
Unravelling a food derived bioactive peptide with dual functionality of antimicrobial and immunomodulatory properties
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)In this thesis, a computational data mining and feature based approach to unravel the abundance of unexplored peptides from nature and to identify potent, novel antimicrobial peptides (AMPs) from phyto-proteins is proposed. ... -
Use of adhesion-defective mutants of Staphylococcus aureus to define the role of specific plasma proteins in promoting bacterial adhesion to canine arteriovenous shunts
(1995)We used an ex vivo canine arteriovenous shunt model, previously developed to study plasma protein adsorption and thrombogenesis on polymeric biomaterials, to define the role of host proteins in promoting adhesion of ... -
Variations in silver stained nucleolar organiser regions(AgNORs) in normal, irradiated and neoplastic tissues
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Nucleolar organiser regions (NORs) are loops of ribosomal DNA which contain the genes that transcribe to ribosomal RNA. They are situated on the short arm of the acrocentric human chromosomes 13, 14, 15, 21 and 22. Several ... -
VirB-mediated positive feedback control of the virulence gene regulatory cascade of Shigella flexneri
(2012)Shigella flexneri is a facultative intracellular pathogen that relies on a type III secretion system and its associated effector proteins to cause bacillary dysentery in humans. The genes that encode this virulence system ... -
Virulence gene regulation by nucleoid associated proteins in Salmonella typhimurium : a role for Fis in Salmonella pathogenicity island 2 gene regulation
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Nucleoid associated proteins are involved in many diverse biological functions in S. typhimurium. In addition to their structural role within the genome they have been im plicated in transcriptional regulation of a variety ... -
When is a transcription factor a NAP?
(2020)Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins ... -
Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG
(2016)Staphylococcus aureus surface protein SasG promotes cell-cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical ...