Browsing School of Engineering by Author "O'Brien, Fergal J."
Now showing items 1-3 of 3
-
Biomaterial-based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies
Kelly, Daniel; Sheehy, Eamon J.; O'Brien, Fergal J. (2019)There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever increasing number of bone grafting procedures performed annually. Herein, we describe a developmentally inspired approach ... -
Composite scaffold development and bioreactor culture for bone tissue engineering
Plunkett, Niamh (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Bone tissue engineering involves seeding bone cells onto a scaffold, culturing this construct so that mineralisation occurs (by using signalling mechanisms such as growth factors or bioreactors) and then implanting it into ... -
Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues
Kelly, Daniel; Dunne, Aisling; Cunniffe, Gráinne M.; Díaz-Payno, Pedro J.; Sheehy, Eamon J.; Critchley, Susan E.; Almeida, Henrique V.; Pitacco, Pierluca; Carroll, Simon F.; Mahon, Olwyn R.; Levingstone, Tanya J.; Moran, Conor J.; Brady, Robert T.; O'Brien, Fergal J.; Brama, Pieter A.J. (2019)Biological scaffolds generated from tissue-derived extracellular matrix (ECM) are commonly used clinically for soft tissue regeneration. Such biomaterials can enhance tissue-specific differentiation of adult stem cells, ...