Browsing School of Engineering by Author "Lally, Caitriona"
Now showing items 1-11 of 11
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An investigation into the influence of cardiovascular stent design on the development of restenosis using the finite element method
Lally, Caitriona (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)Finite element models, which can determine the degree of vascular injury caused to a vessel by a stent and hence ascertain the propensity of that stent design to cause in¬stent restenosis, would be a valuable tool for both ... -
Bovine pericardium of high fibre dispersion has high fatigue life and increased collagen content; potentially an untapped source of heart valve leaflet tissue
Whelan, Alison; Murphy, Bruce; Lally, Caitriona (2020)Bioprosthetic heart valves (BHVs) are implanted in aortic valve stenosis patients to replace the native, dysfunctional valve. Yet, the long-term performance of the glutaraldehyde-fixed bovine pericardium (GLBP) leaflets ... -
Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium
Whelan, Alison; Lally, Caitriona; Murphy, Bruce (2019)The durability of bovine pericardium leaflets employed in bioprosthetic heart valves (BHVs) can significantly limit the longevity of heart valve prostheses. Collagen fibres are the dominant load bearing component of bovine ... -
Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography
Tornifoglio, Brooke; Lally, Caitriona (2021)In this study we investigated the potential of diffusion tensor imaging (DTI) for providing insight into microstructural changes in arterial tissue by exploring the influence that cell, collagen and elastin content have ... -
Ex Vivo Study Using Diffusion Tensor Imaging to Identify Biomarkers of Atherosclerotic Disease in Human Cadaveric Carotid Arteries
Tornifoglio, Brooke; Kerskens, Christian; Lally, Caitriona (2022)Background: This study aims to address the potential of ex vivo diffusion tensor imaging to provide insight into the microstructural composition and morphological arrangement of aged human atherosclerotic carotid ... -
Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering
Kelly, Daniel; Lally, Caitriona (2019)The suitability of a scaffold for tissue engineering is determined by a number of interrelated factors. The biomaterial should be biocompatible and cell instructive, with a porosity and pore interconnectivity that facilitates ... -
Inverse material parameter estimation of patient-specific finite element models at the carotid bifurcation: The impact of excluding the zero-pressure configuration and residual stress
Lally, Caitriona (Wiley, 2023)The carotid bifurcation experiences a complex loading environment due to its anatomical structure. Previous in-vivo material parameter estimation methods often use simplified model geometries, isotropic hyperelastic ... -
Microstructural and mechanical insight into atherosclerotic plaques: an ex vivo DTI study to better assess plaque vulnerability
Tornifoglio, Brooke; Kerskens, Christian; Lally, Caitriona (2023)Non-invasive microstructural characterisation has the potential to determine the stability, or lack thereof, of atherosclerotic plaques and ultimately aid in better assessing plaques’ risk to rupture. If linked with ... -
Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging ? Comparison of intact vs. open cut tissue
GAUL, ROBERT; Kerskens, Christian; Lally, Caitriona (2017) -
Strain mediated Enzymatic Degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp
GAUL, ROBERT; Nolan, David; Lally, Caitriona (2018) -
The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo
GAUL, ROBERT; Lally, Caitriona; Nolan, David (2018)Collagen is the predominant load bearing component in many soft tissues including arterial tissue and is therefore critical in determining the mechanical integrity of such tissues. Degradation of collagen fibres is ...