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dc.contributor.authorMILLS, KINGSTONen
dc.date.accessioned2012-06-26T09:00:42Z
dc.date.available2012-06-26T09:00:42Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationMills KH, TLR-dependent T cell activation in autoimmunity., Nature Reviews Immunology, 11, 12, 2011, 807-22en
dc.identifier.issn1474-1733en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/63990
dc.descriptionPUBLISHEDen
dc.description.abstractAutoimmune disease can develop as a result of a breakdown in immunological tolerance, leading to the activation of self-reactive T cells. There is an established link between infection and human autoimmune diseases. Furthermore, experimental autoimmune diseases can be induced by immunization with autoantigens that are administered together with complete Freund?s adjuvant containing killed Mycobacteria tuberculosis, which in some cases can be replaced with individual pathogen-associated molecular patterns (PAMPs). Exogenous PAMPs and endogenous danger signals from necrotic cells bind to pathogen recognition receptors, including Toll-like receptors, and activate signaling pathways in innate immune cells and on T cells, leading to inflammatory cytokine production and T cell activation, and this is now considered to be a major factor in the development of autoimmunity.en
dc.description.sponsorshipScience Foundation Irelanden
dc.format.extent807-22en
dc.language.isoenen
dc.relation.ispartofseriesNature Reviews Immunologyen
dc.relation.ispartofseries11en
dc.relation.ispartofseries12en
dc.rightsYen
dc.subjectautoimmunityen
dc.subjectTLRen
dc.subjectT cellsen
dc.subjectinfectionen
dc.subjectPAMPsen
dc.subjectDAMPSen
dc.titleTLR-dependent T cell activation in autoimmunity.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/millsken
dc.identifier.rssinternalid77370en
dc.identifier.doihttp://dx.doi.org/10.1038/nri3095en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.orcid_id0000-0003-3646-8222en


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