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dc.contributor.authorFAGAN, ANDREW JOHN
dc.date.accessioned2012-06-18T10:50:52Z
dc.date.available2012-06-18T10:50:52Z
dc.date.issued2012
dc.date.submitted2012en
dc.identifier.citationS. Cournane, J.E. Browne, A.J. Fagan, The effects of fatty deposits on the accuracy of the Fibroscan? liver transient elastography ultrasound system, Physics in Medicine and Biology, 57, 2012, 3901 - 3914en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/63757
dc.descriptionPUBLISHEDen
dc.description.abstractA new generation of ultrasound transient elastography (TE) systems have emerged which exploit the well-known correlation between the liver?s pathological and mechanical properties through measurements of the Young?s elastic modulus; however, little work has been carried out to examine the effect that fatty deposits may have on the TE measurement accuracy. An investigation was carried out on the effects on the measurement accuracy of a transient elastography ultrasound system, the Fibroscan?, caused by overlaying fat layers of varying thickness on healthy liver-mimicking phantoms, simulating in vivo conditions for obese patients. Furthermore, a steatosis effect similar to that in non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) was simulated to investigate its effect on the TE system. A range of novel elastography fat-mimicking materials were developed using 6-10wt% poly(vinyl alcohol) cryogel capable of achieving a range of acoustic velocities (1482-1530m/s) and attenuation coefficients (0.4-1dB/MHz/cm) for simulating different liver states. Laboratory-based acoustic velocities and attenuation coefficients were measured while the Young?s modulus was established through a gold standard compression testing method. A significant variation of the Young?s elastic modulus was measured in healthy phantoms with overlaying fat layers of thicknesses exceeding 45mm, impinging on the scanners region of interest, overestimating the compression tested values by up to 11kPa in some cases. Furthermore, Fibroscan? measurements of the steatosis phantoms showed a consistent overestimation (~54%), which strongly suggests that the speed of sound mismatch between that of liver tissue and that assumed by the scanner is responsible for the high clinical cut-offs established in the case of ALD and NAFLD.en
dc.description.sponsorshipResearch Support Unit in the Dublin Institute of Technology; the Health Research Board, Irelanden
dc.format.extent3901en
dc.format.extent3914en
dc.language.isoenen
dc.publisherInstitute of Physicsen
dc.relation.ispartofseriesPhysics in Medicine and Biology;57
dc.rightsYen
dc.subjecttransient elastographyen
dc.subjectFibroscanen
dc.subjectcryogelen
dc.subjectphantomen
dc.titleThe effects of fatty deposits on the accuracy of the Fibroscan? liver transient elastography ultrasound systemen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/faganan
dc.identifier.rssinternalid79276


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