Show simple item record

dc.contributor.authorKelly, Aineen
dc.contributor.authorO'Mara, Shaneen
dc.date.accessioned2011-10-05T12:49:49Z
dc.date.available2011-10-05T12:49:49Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationGriffin EW, Mulally S, Foley C. Warmington SA. O'Mara SM Kelly ?M, Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males, Physiology & Behavior, 104, 5, 2011, 934-941en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/59831
dc.descriptionPUBLISHEDen
dc.description.abstractPhysical activity has been reported to improve cognitive function in humans and rodents, possibly via a brain-derived neurotrophic factor (BDNF)-regulated mechanism. In this study of human subjects, we have assessed the effects of acute and chronic exercise on performance of a face-name matching task, which recruits the hippocampus and associated structures of the medial temporal lobe, and the Stroop word-colour task, which does not, and have assessed circulating concentrations of BDNF and IGF-1 in parallel. The results show that a short period of high-intensity cycling results in enhancements in performance of the face-name matching, but not the Stroop, task. These changes in cognitive function were paralleled by increased concentration of BDNF, but not IGF-1, in the serum of exercising subjects. 3 weeks of cycling training had no effect on cardiovascular fitness, as assessed by VO2 scores, cognitive function, or serum BDNF concentration. Increases in fitness, cognitive function and serum BDNF response to acute exercise were observed following 5 weeks of aerobic training. These data indicate that both acute and chronic exercise improve medial temporal lobe function concomitant with increased concentrations of BDNF in the serum, suggesting a possible functional role for this neurotrophic factor in exercise-induced cognitive enhancement in humans.en
dc.format.extent934-941en
dc.language.isoenen
dc.relation.ispartofseriesPhysiology & Behavioren
dc.relation.ispartofseries104en
dc.relation.ispartofseries5en
dc.rightsYen
dc.subjectNeuroscienceen
dc.subjectPhysiologyen
dc.subjectbrain-derived neurotrophic factor (BDNF)en
dc.titleAerobic exercise improves hippocampal function and increases BDNF in the serum of young adult malesen
dc.typeJournal Articleen
dc.contributor.sponsorIrish Research Council for Science and Engineering Technology (IRCSET)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/smomaraen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/aikellyen
dc.identifier.rssinternalid73772en
dc.subject.TCDThemeNeuroscienceen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.physbeh.2011.06.005en
dc.identifier.orcid_id0000-0001-8087-8531en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record