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dc.contributor.authorLYNCH, MARINA ANNETTAen
dc.contributor.authorCOSTELLO, DEREKen
dc.date.accessioned2011-08-24T14:25:36Z
dc.date.available2011-08-24T14:25:36Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationDerek A. Costello, Melanie B. Watson, Thelma R. Cowley, Niamh Murphy, Ciaran Murphy Royal, Cecilia Garlanda & Marina A. Lynch, IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice, Journal of Neuroscience, 31, 10, 2011, 3871-3879en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/59034
dc.descriptionPUBLISHEDen
dc.descriptionPubMed ID: 21389242en
dc.description.abstractSingle-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)-1/Toll-like receptor (TLR) family. It negatively regulates inflammation, rendering SIGIRR-/- mice more susceptible to inflammatory challenge. This susceptibility extends to the brain, where increased responsiveness to lipopolysaccharide (LPS) has been observed in SIGIRR-deficient mice. While this is likely due to enhanced TLR4-mediated signalling, the functional consequences of these changes have not yet been described. In the current study, we have investigated the impact of SIGIRR deficiency on hippocampal function, and show that novel object recognition, spatial reference memory and long-term potentiation (LTP) were impaired in SIGIRR-/- mice. These changes were accompanied by increased expression of IL-1RI and TLR4, and up-regulation of their downstream signalling events, namely IRAK1, JNK and NFkappaB. The deficit in LTP was attenuated by the endogenous IL-1 receptor antagonist (IL-1ra) and an anti-TLR4 antibody, and also by inhibition of JNK and NFkappaB. We propose that IL-1RI is activated by IL-1alpha and TLR4 is activated by the endogenous agonist, high mobility group box 1 (HMGB1), as we identified enhanced expression of both cytokines in the hippocampus of SIGIRR-/- mice. Additionally, application of HMGB1 increased the activation of JNK and NFkappaB and was found to be detrimental to LTP in a TLR4-dependent manner. These findings highlight the functional role of SIGIRR in regulating inflammatory-mediated synaptic and cognitive decline, and describe evidence of the key role of HMGB1 in this process.en
dc.description.sponsorshipScience Foundation Ireland - Grant code: 8AA-G20269 This work was supported by Science Foundation Ireland, and a grant from the Sixth Research Framework Programme of the European Union (Projects NoE MUGEN LSHB-CT-2005-005203) to C.G.en
dc.format.extent3871-3879en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Neuroscienceen
dc.relation.ispartofseries31en
dc.relation.ispartofseries10en
dc.rightsYen
dc.subjectLong-term potentiationen
dc.subjectTIR8en
dc.subjectIL-1RIen
dc.subjectTLR4en
dc.subjectNeuroscienceen
dc.titleIL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient miceen
dc.typeJournal Articleen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/decostelen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lynchmaen
dc.identifier.rssinternalid70771en
dc.contributor.sponsorGrantNumber005203en
dc.identifier.rssurihttp://dx.doi.org/10.1523/JNEUROSCI.6676-10.2011en


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