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dc.contributor.authorTONER, MARYen
dc.date.accessioned2011-03-24T15:19:52Z
dc.date.available2011-03-24T15:19:52Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationToner M, O'Regan EM, Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1., Head and neck pathology, 3, 3, 2009, 246-8en
dc.identifier.issn1936-055Xen
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/53797
dc.descriptionPUBLISHEDen
dc.description.abstractWhile most head and neck squamous carcinoma (HNSCC) occurs in older people, an increasing number of young patients are being affected worldwide, with up to 5.5% <40. These are predominantly oral and oropharyngeal cancers. Some patients have heavy exposure to the usual risk factors, but an increasing number do not. Part of this trend appears to be due to rising numbers of HPV associated tonsil carcinoma, particularly in males (smokers and non-smokers). A subset of young patients, however, is non-smoking females usually with tongue cancers, not related to HPV, the aetiology of which is unclear. Various mechanisms may be at work here: the variation in ability to detoxify the products of smoke and alcohol varies in individuals, which may explain why environmental exposure to smoke seems to play a role in some non-smokers with HNSCC. The role of marijuana remains possible but uncertain, and it may be that anaemia is a co-factor. There is an increased risk of HNSCC in first degree relatives of HNSCC patients, and while inherited syndromes associated with HNSCC are rare, elucidation of their genetics may help to develop our understanding the disease in these young patients without recognised risk factors.en
dc.format.extent246-8en
dc.language.isoenen
dc.relation.ispartofseriesHead and neck pathologyen
dc.relation.ispartofseries3en
dc.relation.ispartofseries3en
dc.rightsYen
dc.subjectOncologyen
dc.subjecthead and neck squamous cell carcinoma (HNSCC)en
dc.titleHead and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mtoneren
dc.identifier.rssinternalid72078en
dc.identifier.doihttp://dx.doi.org/10.1007/s12105-009-0135-0en
dc.subject.TCDThemeCanceren


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