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dc.contributor.authorFAGAN, ANDREWen
dc.contributor.authorWETTERLING, FRIEDRICHen
dc.date.accessioned2010-12-10T13:36:45Z
dc.date.available2010-12-10T13:36:45Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationF. Wetterling, M. Tabbert, S Junge, L. Gallagher, I.M. Macrae, A.J. Fagan, A double-tuned 1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI, Physics in Medicine and Biology, 55, 2010, 7681 - 7695en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/41268
dc.descriptionPUBLISHEDen
dc.description.abstractA method for quantifying the Tissue Sodium Concentration (TSC) in the rat brain from 23Na-MR images was developed. TSC is known to change in a variety of common human diseases and holds considerable potential to contribute to their study; however, its accurate measurement in small laboratory animals has been hindered by the extremely low signal to noise ratio (SNR) in 23Na images. To address this, the design, construction and characterisation of a double tuned 1H/23Na dual resonator system for 1H-guided quantitative 23Na-MRI is described. This system comprised of an SNR-optimised surface detector coil for 23Na image acquisition, and a volume resonator producing a highly-homogeneous B1 field (<5% inhomogeneity) for the Na channel across the rat head. The resonators incorporated channel independent balanced matching and tuning capabilities with active decoupling circuitry at the 23Na resonance frequency. A quantification accuracy of TSC of < 10mM was achieved in Na-images with 1.2?l voxel resolution acquired in 10 minutes. The potential of the quantification technique was demonstrated in an in vivo experiment of a rat model of cerebral stroke, where the evolution of the TSC was successfully monitored for 8 hours after the stroke was induced.en
dc.description.sponsorshipThis work was financially supported by Science Foundation Ireland (SFI) under the Research Frontiers Program, grant number ?05/RFP/PHY006?.en
dc.format.extent7681en
dc.format.extent7695en
dc.language.isoenen
dc.relation.ispartofseriesPhysics in Medicine and Biologyen
dc.relation.ispartofseries55en
dc.rightsYen
dc.subjectcerebrovascular systemsen
dc.subjectcerebral strokeen
dc.titleA double-tuned 1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRIen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fagananen
dc.identifier.rssinternalid69150en
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.identifier.rssurihttp://stacks.iop.org/PMB/55/7681en


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