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dc.contributor.authorBELL, ANGUSen
dc.contributor.authorMARIN MENENDEZ, ALEJANDROen
dc.date.accessioned2010-12-09T14:13:59Z
dc.date.available2010-12-09T14:13:59Z
dc.date.created20-22 October 2010en
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationAlejandro Marin-Menendez and Angus Bell, Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives, Malaria Journal, Parasite to Prevention: Advances in the understanding of malaria, Edinburgh, 20-22 October 2010, 9 (Suppl 2), 03, BioMed Central, 2010en
dc.identifier.otherNen
dc.identifier.urihttp://hdl.handle.net/2262/41251
dc.descriptionPUBLISHEDen
dc.descriptionEdinburghen
dc.description.abstractCyclophilins are distributed widely among different organisms and are proposed drug targets for a number of diseases including HIV and hepatitis C infection and ischemia. Cyclophilins play roles in folding and chaperoning of cellular proteins and are the major receptors for the immunosuppressive drug cyclosporin A (CsA). CsA and certain non-immunosuppressive derivatives (e.g., valspodar) possess potent antimalarial activity. We are interested in the role (if any) played by cyclophilins in parasite killing by cyclosporins. We, and others, have previously characterized two CsA-binding cyclophilins (PfCYP19A and PfCYP19B) but a family of genes encoding uncharacterized cyclophilins/cyclophilin-like proteins is also seen in the P. falciparum genome (Figure 1).en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.ispartofseries9 (Suppl 2)en
dc.relation.ispartofseries03en
dc.rightsYen
dc.subjectImmunologyen
dc.titleIdentification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivativesen
dc.title.alternativeMalaria Journalen
dc.title.alternativeParasite to Prevention: Advances in the understanding of malariaen
dc.type.supercollectionscholarly_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/marinmeaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/abellen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/marinmeaen
dc.identifier.rssinternalid69622en
dc.identifier.rssurihttp://dx.doi.org/10.1186/1475-2875-9-S2-O3en


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