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dc.contributor.authorGILL, MICHAELen
dc.contributor.authorLAWLOR, BRIANen
dc.date.accessioned2010-04-12T10:41:17Z
dc.date.available2010-04-12T10:41:17Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationHarold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J, Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease., Nature Genetics, 41, 10, 2009, 1088-1093en
dc.identifier.issn1061-4036en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/38892
dc.descriptionPUBLISHEDen
dc.description.abstractWe undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 x 10(-157)) and observed genome-wide significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8)). These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).en
dc.format.extent1088-1093en
dc.language.isoenen
dc.relation.ispartofseriesNature Geneticsen
dc.relation.ispartofseries41en
dc.relation.ispartofseries10en
dc.rightsYen
dc.subjectgenomeen
dc.subjectAlzheimer's diseaseen
dc.titleGenome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.en
dc.typeJournal Articleen
dc.contributor.sponsorMedical Research Council (MRC)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lawlorbaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.rssinternalid65628en
dc.identifier.doihttp://dx.doi.org/10.1038/ng.440en
dc.subject.TCDThemeGenes & Societyen
dc.identifier.rssurihttp://dx.doi.org/10.1038/ng.440en


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