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dc.contributor.authorCORVIN, AIDEN
dc.contributor.authorGILL, MICHAEL
dc.date.accessioned2009-11-26T16:33:19Z
dc.date.available2009-11-26T16:33:19Z
dc.date.issued2007
dc.date.submitted2007en
dc.identifier.citationJones I, Hanshere M L, Nangle J M, Bennett P, Middle F, Heron J, Segurado R, Lambert D, Williams H, Corvin A, Owen J J, Jones L, Gill M Craddock N `Bipolar affective puerperal psychosis- genome-wide significant evidence for linkage to chromosome 16? in American Journal of Psychiatry, 164, (7), 2007, pp 1 - 6en
dc.identifier.otherY
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/34986
dc.descriptionPUBLISHEDen
dc.description.abstractOBJECTIVE: Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis. METHOD: The authors selected families with bipolar disorder from their previous bipolar disorder genome scan, in which there was at least one family member with a manic or psychotic episode with an onset within 6 weeks of delivery. Individuals were coded as affected if they had been diagnosed with bipolar I disorder; bipolar II disorder; or schizoaffective disorder, bipolar type, according to DSM-IV. A total of 36 pedigrees contributed 54 affected sibling pairs to the cohort. A genome scan with 494 microsatellite markers was analyzed using GENEHUNTER and MAPMAKER/SIBS. RESULTS: A genome-wide significant linkage signal was observed on chromosome 16p13, and a genome-wide suggestive linkage was observed on chromosome 8q24. No significant or suggestive linkage was observed in these regions in our original bipolar scan. CONCLUSIONS: This study identifies chromosomal regions that are likely to harbor genes that predispose individuals to bipolar affective puerperal psychosis. The identification of susceptibility genes would enhance understanding of pathogenesis and offer the possibility of improvements in treatment and risk prediction.en
dc.description.sponsorshipThe authors thank the Wellcome Trust and MRC for funding the research and all the individuals who participated in the study.en
dc.format.extent1en
dc.format.extent6en
dc.format.extent138305 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherAmerican Psychiatric Publishingen
dc.relation.ispartofseriesAmerican Journal of Psychiatryen
dc.relation.ispartofseries164en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectPsychiatryen
dc.titleBipolar affective puerperal psychosis- genome-wide significant evidence for linkage to chromosome 16.en
dc.typeJournal Articleen
dc.contributor.sponsorWellcome Trust
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgill
dc.identifier.rssinternalid36024
dc.identifier.rssurihttp://dx.doi.org/10.1176/appi.ajp.164.7.1099


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