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dc.contributor.authorKELLEHER, DERMOT P
dc.contributor.authorLONG, AIDEEN
dc.date.accessioned2009-10-28T15:45:05Z
dc.date.available2009-10-28T15:45:05Z
dc.date.issued1993
dc.date.submitted1993en
dc.identifier.citationA. Long, M. O'Connell, R. M. Liskamp and D. Kelleher 'Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line' in Immunology, 80, (4), 1993, pp 654-7en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.other21341
dc.identifier.urihttp://hdl.handle.net/2262/34391
dc.descriptionPUBLISHEDen
dc.description.abstractUsing the T-cell lymphoma line HuT 78, and a clone derived from HuT 78, designated K-4, the role of protein kinase C (PKC) isozymes in the expression of a variety of T-cell surface antigens was investigated. HuT 78 expresses PKC isozymes alpha and beta while K-4 expresses only PKC alpha. Flow cytometric analysis revealed that incubation of HuT 78 cells with phorbol 12-myristate 13-acetate (PMA) results in significant down-regulation of surface expression of CD3. While K-4 cells expressed reduced amounts of CD3, a similar reduction in CD3 expression was not observed when these cells were stimulated with PMA. The regulation of expression of CD11a (LFA-1), CD44, CD45RA and CD45RO and of the class II molecules DR and DP in response to PMA, was similar in both cell lines.en
dc.description.sponsorshipD.K. is a Wellcome Senior Fellow in Clinical Science. This work was supported by a grant from the Cancer Research Advancement Board of the Irish Cancer Society.en
dc.format.extent654-7en
dc.format.extent575075 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherBritish Society for Immunologyen
dc.relation.ispartofseriesImmunologyen
dc.relation.ispartofseries80en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectClinical Medicineen
dc.titleRegulation of CD3 expression in a protein kinase C isozyme-deficient T-cell lineen
dc.typeJournal Articleen
dc.contributor.sponsorIrish Cancer Society
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellehdp


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