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dc.contributor.authorMILLS, KINGSTON
dc.date.accessioned2009-09-28T18:39:29Z
dc.date.available2009-09-28T18:39:29Z
dc.date.issued1997
dc.date.submitted1997en
dc.identifier.citationMahon B.P, Griffin F., Sheahan, B. and Mills, K.H.G. `Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in Interferon- Receptor or Immunoglobulin ? Chain Genes? in Journal of Experimental Medicine, 186, (11), 1997, pp 1843 - 1851en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/33376
dc.descriptionPUBLISHEDen
dc.description.abstractUsing a murine respiratory challenge model we have previously demonstrated a role for Th1 cells in natural immunity against Bordetella pertussis, but could not rule out a role for antibody. Here we have demonstrated that B. pertussis respiratory infection of mice with targeted disruptions of the genes for the IFN-? receptor resulted in an atypical disseminated disease which was lethal in a proportion of animals, and was characterized by pyogranulomatous inflammation and postnecrotic scarring in the livers, mesenteric lymph nodes and kidneys. Viable virulent bacteria were detected in the blood and livers of diseased animals. An examination of the course of infection in the lung of IFN-? receptor?deficient, IL-4?deficient and wild-type mice demonstrated that lack of functional IFN-? or IL-4, cytokines that are considered to play major roles in regulating the development of Th1 and Th2 cells, respectively, did not affect the kinetics of bacterial elimination from the lung. In contrast, B cell?deficient mice developed a persistent infection and failed to clear the bacteria after aerosol inoculation. These findings demonstrate an absolute requirement for B cells or their products in the resolution of a primary infection with B. pertussis, but also define a critical role for IFN-? in containing bacteria to the mucosal site of infection.en
dc.description.sponsorshipThis work was supported by a grant from the Wellcome Trust (no. 039583).en
dc.format.extent1843en
dc.format.extent1851en
dc.format.extent332800 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherThe Rockefeller University Pressen
dc.relation.ispartofseriesJournal of Experimental Medicineen
dc.relation.ispartofseries186en
dc.relation.ispartofseries11en
dc.rightsYen
dc.subjectBiochemistryen
dc.titleAtypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in Interferon- Receptor or Immunoglobulin ? Chain Genesen
dc.typeJournal Articleen
dc.contributor.sponsorWellcome Trust
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/millsk


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