Browsing Genetics (Scholarly Publications) by Title
Now showing items 207-226 of 356
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The N-end rule pathway regulates pathogen responses in plants.
(2016)To efficiently counteract pathogens, plants rely on a complex set of immune responses that are tightly regulated to allow the timely activation, appropriate duration and adequate amplitude of defense programs. The coordination ... -
The natural history review (1854-1865)
(2012)ABSTRACT: The natural history review was a quarterly founded in 1854 by Edward Perceval Wright, then an undergraduate student of zoology at Trinity College Dublin. Its first editorial committee (1856? 1860) held traditional ... -
Network plasticity in adaptive filtering and behavioral habituation
(2014)The ability of organisms to seamlessly ignore familiar, inconsequential stimuli improves their selective attention and response to salient features of the environment. Here, I propose that this fundamental but unexplained ... -
Neurogenomics - towards a more rigorous science
(2018)The field of neurogenomics is coming of age, but not without some teething problems. The aim of this field is to understand the genetic basis of differences in brain structure and function, which in turn underlie differences ... -
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines
(2016)IL-36 cytokines require proteolytic processing for activation, but how this is achieved is unknown. Here, Henry et al. show that proteases liberated from activated neutrophils—cathepsin G, elastase, and proteinase-3 ... -
New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
(2015)The origin of novel protein-coding genes de novo was once considered so improbable as to be impossible. In less than a decade, and especially in the last five years, this view has been overturned by extensive evidence from ... -
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila
(2010)Techniques to induce activity-dependent neuronal plasticity in vivo allow the underlying signaling pathways to be studied in their biological context. Here, we demonstrate activity-induced plasticity at neuromuscular ... -
Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice
(2020)Mutations in tubby like protein 1 gene (TULP1) are causative of early-onset recessive inherited retinal degenerations (IRDs); similarly, the Tulp1-/- mouse is also characterized by a rapid IRD. Tulp1 mRNA and protein ... -
Nonconjugated Hydrocarbons as Rigid-Linear Motifs: Isosteres for Material Sciences and Bioorganic and Medicinal Chemistry
(2018)Nonconjugated hydrocarbons, like bicyclo[1.1.1]pentane, bicyclo[2.2.2]octane, triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and shape they are useful mimics of classic benzene ... -
Novel 199 base pair NEFH promoter drives expression in retinal ganglion cells
(2020)Retinal ganglion cells (RGCs) are known to be involved in several ocular disorders, including glaucoma and Leber hereditary optic neuropathy (LHON), and hence represent target cells for gene therapies directed towards these ... -
Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing
(2012)The African buffalo, Synceruscaffer , is one of the most abundant and ecologically important species of megafauna in the savannah ecosystem. It is an important prey species, as well as a host for a vast array of nematodes, ... -
De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences
(2020)Recent evidence demonstrates that novel protein-coding genes can arise de novo from non- genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which ... -
De Novo Genes Arise at a Slow but Steady Rate along the Primate Lineage and Have Been Subject to Incomplete Lineage Sorting
(2016)De novo protein-coding gene origination is increasingly recognized as an important evolutionary mechanism. However, there remains a large amount of uncertainty regarding the frequency of these events and themechanisms and ... -
De novo origin of protein-coding genes in murine rodents.
(2012)Background: New genes in eukaryotes are created through a variety of different mechanisms. De novo origin from non-coding DNA is a mechanism that has recently gained attention. So far, de novo genes have been described in ... -
De Novo Origins of Human Genes
(2011)Where do new genes come from? For a long time the answer to that question has simply been ?from other genes?. The most prolific source of new loci in eukaryotic genomes is gene duplication in all its guises: exon shuffling, ... -
Ohnologs are overrepresented in pathogenic copy number mutations.
(2014)A number of rare copy number variants (CNVs), including both deletions and duplications, have been associated with developmental disorders, including schizophrenia, autism, intellectual disability, and epilepsy. Pathogenicity ... -
Ohnologs in the human genome are dosage balanced and frequently associated with disease
(2010)About 30% of protein-coding genes in the human genome are related through two whole genome duplication (WGD) events. Although WGD is often credited with great evolutionary importance, the processes governing the retention ...
