Browsing Genetics (Scholarly Publications) by Title
Now showing items 139-158 of 356
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Genome-wide deserts for copy number variation in vertebrates
(2013)Most copy number variations are neutral, but some are deleterious and associated with various human diseases. Copy number variations are distributed non-randomly in vertebrate genomes, and it was recently reported that ... -
Genome-Wide Functional Divergence after the Symbiosis of Proteobacteria with Insects Unraveled through a Novel Computational Approach
(2009)Symbiosis has been among the most important evolutionary steps to generate biological complexity. The establishment of symbiosis required an intimate metabolic link between biological systems with different complexity ... -
Genome-wide Mapping of Polycomb Target Genes Unravels Their Roles in Cell Fate Transitions.
(2006)The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Here, we identify their target genes using ... -
A genome-wide resource for the analysis of protein localisation in Drosophila
(2016)The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we ... -
Genomes as documents of evolutionary history: A probabilistic macrosynteny model for the reconstruction of ancestral genomes
(2017)Motivation: It has been argued that whole-genome duplication (WGD) exerted a profound influence on the course of evolution. For the purpose of fully understanding the impact of WGD, several formal algorithms have been ... -
Genomic Features in the Breakpoint Regions between Syntenic Blocks
(Oxford University Press, 2004)MOTIVATION: We study the largely unaligned regions between the syntenic blocks conserved in humans and mice, based on data extracted from the UCSC genome browser. These regions contain evolutionary breakpoints caused by ... -
Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
(PLoS, 2008)We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus ... -
Genomic signals of migration and continuity in Britain before the Anglo-Saxons
(2016)The purported migrations that have formed the peoples of Britain have been the focus of generations of scholarly controversy. However, this has not benefited from direct analyses of ancient genomes. Here we report nine ... -
Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis
(2012)BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure ... -
GlycoRDF: An ontology to standardize glycomics data in RDF
(2015)Motivation: Over the last decades several glycomics-based bioinformatics resources and databases have been created and released to the public. Unfortunately, there is no common standard in the representation of the stored ... -
Greasing the path to BAX/BAK activation
(2012)BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the ... -
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
(2009)Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable ... -
A Highly Unstable Transcript Makes CwlO D, L-Endopeptidase Expression Responsive to Growth Conditions in Bacillus subtilis
(2014)The Bacillus subtilis cell wall is a dynamic structure, composed of peptidoglycan and teichoic acid, that is continually remodeled during growth. Remodeling is effected by the combined activities of penicillin binding ... -
The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors.
(2014)Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly under- stood. The Drosophila Roundabout (Robo) receptors regulate ... -
How Much Is That in Dog Years? The Advent of Canine Population Genomics
(2014)ABSTRACT The authors comment on two studies that analyzed multiple genomes of dogs and wolves. The studies reached different conclusions about the date and population effects, a disparity attributed to reliance on molecular ... -
How to prepare and deliver a great talk
(2019)Giving a talk can be daunting, particularly for scientists at the very early stages of their careers. Standing in front of an audience and speaking for 20–30 minutes do is never easy, and even those who do it for a ...