Browsing School of Biochemistry & Immunology by Author "Akopiants, Konstantin"

Now showing items 1-1 of 1

    • Sestrins inhibit mTORC1 kinase activation through the GATOR complex. 

      Budanov, Andrei; Parmigiani, Anita; Nourbakhsh, Aida; Ding, Boxiao; Wang, Wei; Kim, Young Chul; Akopiants, Konstantin; Guan, Kun-Liang; Karin, Michael (2014)
      The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB ...