Browsing School of Biochemistry & Immunology by Title
Now showing items 908-927 of 1015
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T cell receptor signaing controls Foxp3 expression via PI3K, Akt and mTOR.
(National Academy of Sciences, 2008)Regulatory T (Treg) cells safeguard against autoimmunity and immune pathology. Because determinants of the Treg cell fate are not completely understood, we have delineated signaling events that control the de novo expression ... -
T cell subpopulations in B cell chronic lymphocytic leukemias
(British Society for Immunology, 1984) -
T cells in experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Multiple sclerosis (MS) is an intlammatory, demyelinating disease of the central nervous system (CNS) that is both clinically and pathologically heterogeneous. Studies in experimental autoimmune encephalomyelitis (EAE), ... -
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
(2010)Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous system (CNS), which involves autoimmune responses to myelin antigens. Studies in experimental autoimmune encephalomyelitis (EAE), ... -
Targeted nasal vaccination provides antibody-independent protection against staphylococcus aureus
(2014)Despite showing promise in preclinical models, anti – Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsoniz- ing antibodies; however, vaccines exclusively ... -
Technological Approaches for Improving Vaccination Compliance and Coverage
(2020)Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical ... -
A temperature gradient method for lipid phase diagram construction using time-resolved x-ray diffraction.
(1987)A method that enables temperature-composition phase diagram construction at unprecedented rates is described and evaluated. The method involves establishing a known temperature gradient along the length of a metal rod. ... -
Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of Vα14 iNKT cells, regulatory T cells and conventional T cells
(2010)The present study uses two independent genetic strategies to explore the requirement for Phosphoinositide dependent kinase-1 (PDK1) in the development of mature T cell populations from CD4/CD8 double positive thymocytes. ... -
A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression
(2006)Insulin regulation of hepatic gene transcription is a vital component of glucose homeostasis. Understanding the molecular regulationof thisprocess aids the searchfor the defect(s) that promotesinsulin-resistant states, ... -
Ternary structure reveals mechanism of a membrane diacylglycerol kinase
(2015)Diacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per ... -
Ternary structure reveals mechanism of a membrane diacylglycerol kinase
(2015)Diacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per ... -
TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
(2021)Background Natural killer (NK) cells provide important immune protection from cancer and are a key requirement for particular immunotherapies. There is accumulating evidence that NK cells become dysfunctional during cancer. ... -
Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
(Elsevier, 2009)Autophagy is a recently recognized immune effector mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune ... -
Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T cell subsets as Th1, Th2 or Th0
(British Society for Immunology, 1996)In studies of the mechanism of immunity to Bordetella pertussis in a murine respiratory infection model, we have previously demonstrated that natural infection of immunization with a whole cell vaccine induces a potent ... -
The alcohol dehydrogenases of Bacillus stearothermophilus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)A 1.5-kb fragment of Bacillus stearothermophilus DSM 2334 DNA was subcloned into pUC18, and the nucleotide sequence was determined. The fragment contained a complete open reading frame that encoded a 339-residue amino-acid ... -
The characterisation of Human Vδ3 T cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Human γδ T cells expressing the Vδ3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. We analysed the frequencies, phenotypes, ... -
The development of fish epithelial cell lines and primary cultures as diagnostic tools in environmental risk assessment
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The objective of the this study was to attempt and develop fish epithelial cellular markers as diagnostic tools for effects assessment in ecotoxicolgy using established cell lines and primary cultures. As a target group ... -
The establishment of hybrid cell lines from human pancreas
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)The need for research into diabetes mellitus is ever increasing. Of specific interest are the mechanisms responsible for glucose-responsive insulin secretion and the autoimmune destruction of pancreatic p-cells. However, ...