Browsing School of Biochemistry & Immunology by Title
Now showing items 818-837 of 1015
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SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter
(2014)The four Toll/IL-1R domain-containing adaptor proteins MyD88, MAL, TRIF, and TRAM are well established as essential mediators of TLR signaling and gene induction following microbial detection. In contrast, the function of ... -
SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.
(2014)The four Toll/IL-1R domain-containing adaptor proteins MyD88, MAL, TRIF, and TRAM are well established as essential mediators of TLR signaling and gene induction following microbial detection. In contrast, the function of ... -
Schistosoma mansoni modulation of allergic responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)It has been proposed that in humans infection with certain parasitic helminths may reduce the propensity to develop allergies in infected populations. Schistosoma mansoni is a parasitic trematode that is implicated as a ... -
Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1
(2005)Schlafen-1 (Slfn-1), the prototypic member of the Schlafen family of proteins, was described as an inducer of growth arrest in T-lymphocytes and causes a cell cycle arrest in NIH3T3 fibroblasts prior to the G1/S transition. ... -
Screening for vitamin B-12 and folate deficiency in older persons
(American Society for Clinical Nutrition, 2003)Background: Vitamin B-12 deficiency is usually accompanied by elevated concentrations of serum total homocysteine (tHcy) and methylmalonic acid (MMA). Folate deficiency also results in elevated tHcy. Measurement of these ... -
Semicarbazide-sensitive amine oxidase & 5-HT in dental pulp
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)This thesis investigated the behavior of semicarbazide sensitive amine oxidase (SSAO) and the unique activity that it possesses towards 5-hydroxytryptamine (5-HT) in various dental pulp tissues. This summary presents the ... -
Sensing and Signaling in Antiviral Innate Immunity
(2010)Viruses are detected by the innate immune system, leading to the initiation of the anti-viral immune response via the production of type I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress ... -
Serotonin transporter ligands as anticancer agents : investigations into a mechanism-based therapy for Burkitt's lymphoma and related malignancies
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The recent discovery that some serotonin transporter (SERT) ligands have the potential to act as pro-apoptotic agents in Burkitt’s lymphoma adds greatly to their diverse pharmacological application and is the primary focus ... -
Sestrin family - the stem controlling healthy ageing
(2020)Sestrins are a family of stress-responsive antioxidant proteins responsible for regulation of cell viability and metabolism. The best known Sestrin targets are mTORC1 and mTORC2 kinases that control different cellular ... -
Sestrin prevents muscle atrophy from disuse and aging by integrating anabolic and catabolic signals.
(2020)A unique property of skeletal muscle is its ability to adapt its mass to changes in activity. Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength, leading to physical incapacity and ... -
Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells.
(2016)Objectives: Sestrin-2 (Sesn2) belongs to a family of highly conserved antioxidant proteins that were discovered as p53-inducible proteins and inhibits cell growth and proliferation. Our aim was to assess the levels of Sesn2 ... -
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
(2016)Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by ... -
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
(2014)The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB ... -
Sestrins Link Tumor Suppressors with the AMPK -TOR Signaling Network
(InTech, 2012)The strength of the mechanisms involved in the control of health and lifespan determines the rate of aging in any organism. Aging is fueled by the accumulation of damage in a multitude of tissues, causing many age-related ... -
Sestrins orchestrate cellular metabolism to attenuate aging
(2013)The Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By ... -
Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis
(2022)MS is an autoimmune disease of the CNS that afflicts over 2.5 million people world-wide. There are striking sex differences in the susceptibility to and progression of thisdisease in humans. Females are twice as likely to ... -
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
(British Society for Immunology, 2004)An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress ... -
Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
(Society of Leukocyte Biology, 1998)Interleukin-1 (IL-1) is a central regulator of the immune and inflammatory responses. Recently, significant advances have been made in the area of IL-1 receptors and IL-1 signal transduction. A family of proteins has been ... -
Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
(2007)Toll-like receptors (TLRs) are a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. TLR7 and TLR8 sense single-stranded RNA from viruses or host ribonucleoproteins ...