Browsing School of Biochemistry & Immunology by Title
Now showing items 680-699 of 1015
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Omega-3 fatty acids attenuate dendritic cell function via NF-kappa B independent of PPAR gamma
(2011)Long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to modulate the immune response and have therapeutic effects in inflammatory disorders. PUFA are also peroxisome proliferators-activator receptor-gamma ... -
Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells
(2011)Inhaled therapies in the form of drugs or vaccines for tuberculosis treatment were reported about a decade ago. Experts around the world met to discuss the scientific progress in inhaled therapies at the international ... -
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses
(2019)Helicobacter pylori causes chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development. Although much effort has been put into the development of a Helicobacter ... -
Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain.
(1992)White Leghorn hens were immunized with enterotoxigenic Escherichia coli B16-4 with heat-labile enterotoxin and colonization factor antigen I in Freund's adjuvant. Specific antibodies were detected by an enzyme-linked ... -
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism
(2020)A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprogramming of immune cells, including ... -
Overcoming waning immunity in pertussis vaccines: Workshop of the national institute of allergy and infectious diseases
(2020)Despite high vaccine coverage in many parts of the world, pertussis is resurging in a number of areas in which acellular vaccines are the primary vaccine administered to infants and young children. This is attributed in ... -
An overview of current knowledge of deadly covs and their interface with innate immunity
(2021)Coronaviruses are a large family of zoonotic RNA viruses, whose infection can lead to mild or lethal respiratory tract disease. Severe Acute Respiratory Syndrome-Coronavirus-1 (SARS-CoV-1) first emerged in Guangdong, China ... -
Oxysterols - new players in regulation of Natural Killer cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Natural Killer (NK) cells are cytotoxic, innate lymphocytes that play a crucial role in mediating viral and tumour responses as well as supporting tissue homeostasis. Due to their fast acting immune response independent ... -
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
(2008)The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose ... -
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
(2019)SESTRINs (SESN1-3) are proteins encoded by an evolutionarily conserved gene family that plays an important role in the regulation of cell viability and metabolism in response to stress. Many of the effects of SESTRINs are ... -
Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from synaptosomes
(2008)Mitochondria have been implicated in the pathogenesis of several neurodegenerative disorders and, in particular, complex I (NADH:ubiquinone oxidoreductase, EC 1.6.5.3) activity has been shown to be partially reduced in ... -
Particulate adjuvants for use in cancer vaccination
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)It is estimated that 1 in 2 people will develop cancer in their lifetime, highlighting the urgent need for improved preventative and therapeutic strategies. Cancer immunotherapy has emerged as a key pillar of cancer ... -
Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells: A Novel Strategy for Evasion of Protective T Helper Type 1 Responses by Bordetella pertussis
(Rockefeller University Press, 2002)Antigen-specific T helper type 1 (Th1) cells mediate protective immunity against a range of infectious diseases, including that caused by Bordetella pertussis. Distinct T cell subtypes that secrete interleukin (IL)-10 or ... -
PATHOGENIC PROTEIN AGGREGATION IN VIVO AND IN VITRO
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Neurodegenerative disorders (ND) such as Alzheimer?s disease (AD), Parkinson?s disease (PD) and amyotrophic lateral sclerosis (ALS) are one of the leading causes of death and disabilities worldwide. While their aetiologies ... -
PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
(2012)mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the ... -
The peripheral cannabinoid receptor type 1 (CB1) as a molecular target for modulating body weight in man
(2021)The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted central side effects of both agonists (in wasting disorders) or antagonists (in obesity and diabetes) have limited their therapeutic ... -
Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?
(BioMed Central, 2009)BACKGROUND: Ireland is an example of a country that has extensive voluntary fortification with folic acid. After a public consultation process, in 2006, the Food Safety Authority in Ireland FSAI 1 recommended mandatory ... -
Personalised nutrition Genetic variation and disease risk: new advances
(Cambridge University Press, 2009)Variations in human DNA, most frequently single-nucleotide polymorphisms (SNPs), can have functional consequences ranging from severe to none. Variations in outcome (phenotype) can be compared, from cystic fibrosis through ...