Browsing School of Biochemistry & Immunology by Title
Now showing items 371-390 of 1015
-
Identification and characterisation of proteins from the tomato lectin binding fraction of Trypanosoma brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)African trypanosomes, of which Trypanosoma brucei may be considered a prototypic member, are protozoan parasites responsible for sleeping sickness in man and related diseases in cattle and other domestic animals. Although ... -
Identification and characterisation of serotonin transporter interacting proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)The serotonin transporter (SERT) is an integral plasma membrane protein that mediates the high-affinity re-uptake of the neurotransmitter serotonin from the synaptic space. SERT is of particular clinical and phannacological ... -
Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei
(2013)Flagellar attachment is a visibly striking morphological feature of African trypanosomes but little is known about the requirements for attachment at a molecular level. This study characterizes a previously undescribed ... -
Identification and Characterization of an Unusual Class I Myosin Involved in Vesicle Traffic in Trypanosoma brucei
(2010)Myosins are a multimember family of motor proteins with diverse functions in eukaryotic cells. African trypanosomes possess only two candidate myosins and thus represent a useful system for functional analysis of these ... -
Identification of Anticoagulant Properties of Dimethyl Fumarate and 4-Octyl Itaconate via Suppression of the Macrophage Type I Interferon-Tissue Factor Axis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The host response to infection is characterized by activation of the innate immune and blood coagulation systems, which collectively detect, neutralize, and prevent dissemination of the invading pathogen, maintaining ... -
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
(2004)We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by PKB ? (protein kinase B ? ), but not by SGK1 (serum- and glucocorticoid-induced kinase 1), and ident- ified it as the ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
Identification of Plasmepsin Inhibitors as Selective Antimalarial Agents using Ligand Based Drug Design
(Elsevier, 2011)We describe the application of Ligand Based Virtual Screening technologies towards the discovery of novel Plasmepsin (PM) inhibitors, a family of malarial parasitic aspartyl proteases. Pharmacophore queries were used to ... -
Identification of the components of the eukaryotic queuine transglycosylase complex and the effect of its substrate queuine on metabolism
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Queuine is a 7-deazaguanine derivative of guanine, which replaces guanine in position 34 of the anticodon loop of the transfer RNA for the amino acids, asparagine, aspartic acid, histidine and tyrosine. This base or related ... -
Identification of the mammalian queuine transfer RNA ribosyltransferase complex and characterisation of QTRT1 gene-trap mice deficient in queuosine modified transfer RNA
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Queuine, or Q-base, is a modified form of 7-deazaguanine that is synthesised de novo by eubacteria, but which is obtained from food or the gut flora by eukaryotes. Q-base is enzymatically inserted into the wobble position ... -
IFI16 is an innate immune sensor for intracellular DNA
(2010)The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA ... -
IFNL cytokines do not modulate human or murine NK cell functions
(2014)The interferon-lambda (IFNL) cytokines have been shown to be important in HCV infection with SNPs in the IFNL3 gene associated with both natural and treatment induced viral clearance. We have recently shown that rs1299860 ... -
IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65
(The American Society for Biochemistry and Molecular Biology, 2006)The members of the NF-?B transcription factor family are key regulators of gene expression in the immune response. Different combinations of NF-?B subunits not only diverge in timing to induce transcription but also recognize ... -
IL-10 inhibits miR-155 induction by Toll-like receptors.
(2010)IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs ... -
IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
(2017)IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown ... -
IL-17 and IL-17-producing cells in protection versus pathology
(2023)IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced ... -
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F + neutrophils
(2021)Understanding the mechanism of protective immunity in the nasal mucosae is central to the design of more effective vaccines that prevent nasal infection and transmission of Bordetella pertussis. We found significant ... -
IL-27 mediates the response to IFN beta therapy in multiple sclerosis patients by inhibiting Th17 cells
(2011)Interferon (IFN)-? is a commonly used therapy for relapsing remitting multiple sclerosis (RRMS). However its protective mechanism is still unclear and the failure of many patients to respond has not been explained. We have ... -
IL-33 regulates the immune response to particulate vaccine adjuvants
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Vaccines are one of the most successful tools contributing to global health. Despite their success, further research into safe and efficient vaccination is required to address two key issues; to combat emerging infectious ...