Browsing School of Biochemistry & Immunology by Title
Now showing items 337-356 of 1015
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HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Oral and oesophageal cancers are aggressive tumours that are frequently diagnosed late, with high morbidity, mortality, and difficulties in surgical and therapeutic intervention. Novel imaging probes could assist in early ... -
Harnessing poxviral know-how for anti-cytokine therapies
(2019)Poxviruses have evolved efficient proteins that bind mammalian cytokines and chemokines to suppress host immunity. HerePontejoet al.examine in detail how one such poxviral protein,CrmD, that has activity against both ... -
Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections.
(2014)Enteric infections are a major cause of mortality and morbidity with significant social and economic implications worldwide and particularly in developing countries. An attractive approach to minimizing the impact of these ... -
Harnessing the therapeutic properties of the Heme Oxygenase system
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The stress response enzyme, Heme Oxygenase 1 (HO-1), has been identified as an important immunomodulator which is highly upregulated in response to cellular stress and inflammation. HO-1 catalyses the conversion of free ... -
HCV evasion of IFN-alpha signalling : implications for therapy
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Successful anti-viral immunity is dependent on effective activation of the innate immune response. The majority of individuals infected with hepatitis C virus (HCV) fail to eliminate the virus and progress to chronic ... -
The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3
(2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
Helminth products promote anti-inflammatory trained innate immunity by imprinting long-term hematopoietic stem cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Recent research has shown that immunological memory is not confined to the cells of the adaptive immune system but can be imbued upon innate immune cells, including monocytes and macrophages, in a process known as trained ... -
Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development.
(2004)Interleukin 15 (IL-15) is critical for the development of human and murine natural killer (NK) cells and hepatic-derived NK T cells (NKT) in mice, and for the homeostatic maintenance of NK/NKT and CD8(+) memory T cells. ... -
The hepatic microenvironment and immune cell recruitment in colorectal liver metastasis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The liver is uniquely enriched with anti-tumour immune cells. However, liver metastasis is anticipated in over half of colorectal cancer patients. The value of the type and location of immune cells to prognosis has been ... -
Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses.
(2014)TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of ... -
The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3
(2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
Hepatitis C Virus targets the Interferon-? JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.
(2013)JAK/STAT signalling is essential for anti-viral immunity, making IFN-α an obvious anti-viral therapeutic. However, many HCV+ patients fail treatment, indicating that the virus blocks successful IFN-α signalling. We found ... -
Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver
(2021)5-Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis in vertebrate species; a re- action catalyzed by the mitochondrial ALA synthase 1 (ALAS1) enzyme. Previously we reported that knockdown of ... -
The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19
(2021)The COVID-19 pandemic has led to over 92 million cases and 1.9 million deaths worldwide since its outbreak. Public health responses have focused on identifying symptomatic individuals to halt spread. However, evidence ... -
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
(1999)In this study, we compared the influence of two peptides on the selection of CD8alphaalpha and CD8alphabeta intraepithelial lymphocytes (IELs) of the intestine, which develop by a unique and partially thymus-independent ... -
High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal
(2011)Background: The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's ... -
High-throughput Automated System for Crystallizing Membrane Proteins in Lipidic Mesophases.
(2007)A high-throughput robotic system has been developed to enable the automatic handling of nanoliter volumes of highly viscous biomaterials for crystallizing membrane proteins using lipidic mesophases. The in meso method ... -
A highly efficient blocked Gibbs sampler reconstruction of multidimensional NMR spectra
(2010)Projection Reconstruction Nuclear Magnetic Resonance (PR-NMR) is a new technique to generate multi-dimensional NMR spectra, which have discrete features that are relatively sparsely distributed in space. A small number ... -
Histological changes associated with wheat protein antibodies in the absence of villous atrophy.
(1987)A retrospective study was conducted to assess the association of alpha-gliadin antibodies with intraepithelial lymphocyte counts. Twelve subjects with apparently normal small intestinal histology and raised alpha-gliadin ...