Browsing School of Biochemistry & Immunology by Title
Now showing items 204-223 of 1015
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Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production
(2019)Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the ... -
Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells
(The American Society for Biochemistry and Molecular Biology, 1997)The anthracycline antibiotic, daunorubicin, can induce programmed cell death (apoptosis) in cells. Recent work suggests that this event is mediated by ceramide via enhanced ceramide synthase activity. Since the generation ... -
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
(2018)Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of ... -
Delayed cell death in human and fish skin cell lines after exposure to UVA and UVB
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The effects of ultraviolet radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UVA and UVB. This study compares the effects of UVA ... -
Delineating molecular mechanisms of inflammation-induced delirium using a novel mouse model
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Delirium is a syndrome of acute and transient confusion with disruption of attention and cognition; it is a common but underdiagnosed neuropsychiatric condition, which is predictive of increased fimctional decline, dementia ... -
Delineating the mechanisms utilised by Staphylococcus aureus to survive intracellularly within phagocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major human pathogen in addition to being an important part of the human microbiome. The bacterium has evolved a large array of immune evasion mechanisms to facilitate its persistence ... -
Delirium
(2020)Delirium, a syndrome characterized by an acute change in attention, awareness and cognition, is caused by a medical condition that cannot be better explained by a pre-existing neurocognitive disorder. Multiple predisposing ... -
Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study.
(2012)Recent studies suggest that delirium is associated with risk of dementia and also acceleration of decline in existing dementia. However, previous studies may have been confounded by incomplete ascertainment of cognitive ... -
Delivery strategies to enhance oral vaccination against enteric infections
(2015)While the majority of human pathogens infect the body through mucosal sites, most licensed vaccines are injectable. In fact the only mucosal vaccine that has been widely used globally for infant and childhood vaccination ... -
Dendritic cell mediated mucosal cross talk
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Developing efficacious vaccines against enteric diseases is a global challenge and priority. The rational design of such vaccines requires that novel pathways of cellular recruitment to the gastrointestinal (GI) tract be ... -
Depletion of glutathione does not affect electron transport chain complex activities in brain mitochondria: Implications for Parkinsons's disease and postmortem studies
(2011)Glutathione is an important antioxidant in the brain that appears to be decreased, in conjunction with mitochondrial complex I activity, in Parkinson?s disease patients. In postmortem analysis, measurement of glutathione ... -
Derivation of dopaminergic neurons from embryonic and induced pluripotent stem cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Dopamine (DA) neurons have several fundamental functions in the brain, dysfunction of which has been implicated in neurological and psychiatric disorders, including Parkinson’s disease (PD) and schizophrenia. Embryonic ... -
Detecting microRNA activity from gene expression data.
(2010)ABSTRACT: BACKGROUND: MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the messenger RNA (mRNA) of protein coding genes. They control gene expression by either inhibiting translation or ... -
Detection of Viral Infections by Innate Immunity
(2021)Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to viral ... -
Detection, expression and elucidation of the mechanism of action of mitochondrial uncoupling Protein 1
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)A system for overexpression of recombinant proteins in E. coli is defined. Using subcloning techniques the cDNAs for human uncoupling proteins (hUCP) 1, 2 and 3 were introduced to the pET expression system for E. coli. ... -
Detergents Destabilize the Cubic Phase of Monoolein. Implications for Membrane Protein Crystallization.
(Elsevier, 2003)The in meso method for membrane protein crystallization uses a lipidic cubic phase as the hosting medium. The cubic phase provides a lipid bilayer into which the protein presumably reconstitutes and from which protein ... -
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility
(Nature Research, 2011)Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific ... -
Development and application of novel virtual High Throughput Screening (vHTS) Technologies
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)The development of new pharmaceutical drugs is an expensive, timeconsuming task with an often low success rate. Traditionally, once a therapeutic target and its role in disease is identified, the process of identification ...