Browsing School of Biochemistry & Immunology by Title
Now showing items 82-101 of 1015
-
Bacterial products as activators of NF-ϰB
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)The ability of bacterial products to potently activate NF-xB has made this transcription factor one of the most widely studied in the immune response. A greater understanding of the mechanisms and signal transduction ... -
Bernal and the genesis of structural biology.
(2007)I was invited to participate in this Symposium a month or so before the event. At that time however, I knew little about J D Bernal. I vaguely remembered a brief conversation on the topic over a decade ago with Professor ... -
The Biochemical and Bioenergetic Consequences of the Myostatin SNP g.66493737C>T and SINE insertion 227 bp polymorphism in Skeletal Muscle of Thoroughbred Horses
(2017)The Thoroughbred horse is a tremendous athletic breed, which can be attributed to years of genetic selection for speed and stamina. This selection has led to the Thoroughbred having a very high aerobic capacity relative ... -
Biochemical characterization of the human queine insertase complex
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Queuine is a bacterial metabolite that is salvaged by almost all eukaryotic species including algae, yeast, fungi and metazoans and is incorporated into transfer RNA for the amino acids asparagine, aspartic acid, histidine ... -
Biochemical investigations of hyperhomocysteinemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Hyperhomocysteinemia, a condition where plasma homocysteine occurs at an abnormally elevated level, is a common finding in vascular disease subjects. Several genetic and nutritional factors have been implicated. The first ... -
Bioenergetics and mitochondrial dynamics in cancer cells and neurons
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Mitochondria in mammalian cells exist as a highly dynamic and interconnected reticulum. This reticular ultrastructure is defined by the opposing forces of fission and fusion, mainly mediated by a group of large GTPases ... -
Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells
(2017)Acquired cisplatin resistance is a common feature of tumours following cancer treatment with cisplatin and also of non-small cell lung cancer (H1299) and mesothelioma (P31) cell lines exposed to cisplatin. To elucidate the ... -
A Bioenergetics Study of Mitochondrial Function in Bone Marrow Derived Macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Mitochondria are organelles involved in the generation of ATP, storage of intracellular calcium ions, regulation of the apoptotic pathway as well as numerous cell signalling pathways. Moreover, mitochondria are an important ... -
Biological roles of semicarbazide sensitive amine oxidase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)SSAO is a multifunctional protein that catalyses the oxidative deamination of primary amines, according to the overall reaction RCH2NH2 + O2 + H2O -» RCHO + NH3 + H2O2. In this work, some of the recognised physiological ... -
Biophysical Investigations of the Specificity between Rab GTPases and their Effectors
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The specificity of protein-protein interactions is a complex process that is poorly understood and difficult to predict. Understanding the molecular basis for specificity of a protein and its binding partner requires a ... -
Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures.
(2011)Introduction: The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells. Methods: RA synovial tissue biopsies, obtained under direct visualization ... -
Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells
(2013)The immune system has evolved regulatory mechanisms to control immune responses to self-antigens. Regulatory T (Treg) cells play a pivotal role in maintaining immune tolerance, but tumour growth is associated with local ... -
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE against pertussis toxin but not against common allergens
(British Society for Immunology, 2000)Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also ... -
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
(2014)Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that ... -
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death
(The American Association of Immunologists, 2005)Adenylate cyclase toxin (CyaA) of Bordetella pertussis belongs to the repeat in toxin family of pore-forming toxins, which require posttranslational acylation to lyse eukaryotic cells. CyaA modulates dendritic cell (DC) ... -
Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses.
(American Society for Microbiology, 2008)Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ... -
Both TLR2 and TRIF contribute to interferon-? production during Listeria infection.
(2012)Synthesis of interferon-? (IFN-?) is an innate response to cytoplasmic infection with bacterial pathogens. Our recent studies showed that Listeria monocytogenes limits immune detection and IFN-? synthesis via deacetylation ... -
Bovine b946;-defensin gene family: Opportunities to improve animal health?
(2014)Recent analysis of the bovine genome revealed an expanded suite of β-defensin genes that encode what are referred to as antimicrobial or host defense peptides (HDPs). Whereas primate genomes also encode α- and θ-defensins, ...