Browsing School of Biochemistry & Immunology by Title
Now showing items 978-997 of 1015
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Tregs and transplantation tolerance
(2004)The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to ... -
Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling
(National Academy of Sciences, 2006)PKC? has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKC? in LPS signaling is unknown. LPS signaling is mediated by Toll-like receptor 4, which uses four ... -
TRIL is involved in cytokine production in the brain following escherichia coli infection
(2014)TLR4 interactor with leucine-rich repeats (TRIL) is a brain-enriched accessory protein that is important in TLR3 and TLR4 signaling. In this study, we generated Tril(-/-) mice and examined TLR responses in vitro and in ... -
The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling
(2007)Signaling by two of the most important bacteria-sensing TLRs, TLR2 and TLR4, involves two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adaptor-inducing IFN-? (Trif)-related ... -
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
(2015)The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our ... -
Tubulin-targeting antiparasitic herbicides : new insights into putative ligand-binding pockets and computational design of molecular equivalents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Neglected diseases are a group of tropical infections which are especially endemic in lowincome populations in developing regions of Africa, Asia, and the Americas. Collectively these diseases affect more more than a biUion ... -
Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis
(University of Chicago, 2008)umor necrosis factor (TNF)?? is a proinflammatory cytokine that mediates inflammation in response to various pathogens, including Mycobacterium tuberculosis, but is also a key factor in the pathogenesis of rheumatoid ... -
Tumour derived microRNA-21 reprograms macrophage responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)The role of the oncogenic yet anti-inflammatory microRNA-21 (miR-21) in the tumour microenvironment (TME) is not clearly defined, despite its upregulation in many cancers. Since re-education of macrophages by tumour derived ... -
Turning 21: Induction of miR-21 as a key switch in the inflammatory response
(2015)miR-21 is one of the most highly expressed members of the small non-coding microRNA family in many mammalian cell types. Its expression is further enhanced in many diseased states including solid tumors, cardiac injury, ... -
Two new and rapid approaches for studying the phase properties of cosmetic lipids and oils
(Society of Cosmetic Chemists, 1988)Lipids and oils, integral components of cosmetic products, exist in a number of intermediate physical states, or mesomorphic phases, between the crystalline solid and isotropic liquid. The stability of these phases depends ... -
Type ii nkt cell agonist, sulfatide, is an effective adjuvant for oral heat-killed cholera vaccines
(2021)Oral vaccination has the potential to offer a safer and more efficacious approach for protection against enteric pathogens than injection-based approaches, especially in developing countries. One key advantage is the ... -
Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
(American Society for Biochemistry and Molecular Biology, 2008)Toll-like receptor 4 (TLR4) recognition of lipopolysaccharide triggers signalosome assembly among TLR4, sorting (e.g. MyD88 adapter-like (Mal)) and signaling (e.g. MyD88) adapters, initiating recruitment and activation of ... -
UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation
(2020)Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. We have previously reported UCP3 ... -
Uncoupling mechanism and redox regulations of mitochondrial uncoupling protein UCP1
(2018)Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these ... -
Understanding the mechanism and functional effects of caspase-11 regulated nitric oxide production during inflammation and cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Inflammatory caspases are a group of cysteine aspartic proteinases essential for the inflammatory process, but when dysregulated are implicated in inflammatory diseases and cancer-associated chronic inflammatory events. ... -
Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways
(2010)Detection of viral nucleic acid within infected cells is essential to an effective antiviral response. The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLR) form part of the virus detection repertoire and are ... -
Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease
(2021)The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development ... -
Unravelling the inflammatory landscape of hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease characterised by painful lesions at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Follicular ... -
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
(2009)Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) ... -
Use of a Robot for High-throughput Crystallization of Membrane Proteins in Lipidic Mesophases
(2012)An important route to understanding how proteins function at a mechanistic level is to have the structure of the target protein available, ideally at atomic resolution. Presently, there is only one way to capture such ...