Browsing School of Biochemistry & Immunology by Title
Now showing items 88-107 of 1015
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Biochemical investigations of hyperhomocysteinemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Hyperhomocysteinemia, a condition where plasma homocysteine occurs at an abnormally elevated level, is a common finding in vascular disease subjects. Several genetic and nutritional factors have been implicated. The first ... -
Bioenergetics and mitochondrial dynamics in cancer cells and neurons
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Mitochondria in mammalian cells exist as a highly dynamic and interconnected reticulum. This reticular ultrastructure is defined by the opposing forces of fission and fusion, mainly mediated by a group of large GTPases ... -
Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells
(2017)Acquired cisplatin resistance is a common feature of tumours following cancer treatment with cisplatin and also of non-small cell lung cancer (H1299) and mesothelioma (P31) cell lines exposed to cisplatin. To elucidate the ... -
A Bioenergetics Study of Mitochondrial Function in Bone Marrow Derived Macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Mitochondria are organelles involved in the generation of ATP, storage of intracellular calcium ions, regulation of the apoptotic pathway as well as numerous cell signalling pathways. Moreover, mitochondria are an important ... -
Biological roles of semicarbazide sensitive amine oxidase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)SSAO is a multifunctional protein that catalyses the oxidative deamination of primary amines, according to the overall reaction RCH2NH2 + O2 + H2O -» RCHO + NH3 + H2O2. In this work, some of the recognised physiological ... -
Biophysical Investigations of the Specificity between Rab GTPases and their Effectors
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The specificity of protein-protein interactions is a complex process that is poorly understood and difficult to predict. Understanding the molecular basis for specificity of a protein and its binding partner requires a ... -
Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures.
(2011)Introduction: The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells. Methods: RA synovial tissue biopsies, obtained under direct visualization ... -
Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells
(2013)The immune system has evolved regulatory mechanisms to control immune responses to self-antigens. Regulatory T (Treg) cells play a pivotal role in maintaining immune tolerance, but tumour growth is associated with local ... -
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE against pertussis toxin but not against common allergens
(British Society for Immunology, 2000)Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also ... -
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
(2014)Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that ... -
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death
(The American Association of Immunologists, 2005)Adenylate cyclase toxin (CyaA) of Bordetella pertussis belongs to the repeat in toxin family of pore-forming toxins, which require posttranslational acylation to lyse eukaryotic cells. CyaA modulates dendritic cell (DC) ... -
Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses.
(American Society for Microbiology, 2008)Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ... -
Both TLR2 and TRIF contribute to interferon-? production during Listeria infection.
(2012)Synthesis of interferon-? (IFN-?) is an innate response to cytoplasmic infection with bacterial pathogens. Our recent studies showed that Listeria monocytogenes limits immune detection and IFN-? synthesis via deacetylation ... -
Bovine b946;-defensin gene family: Opportunities to improve animal health?
(2014)Recent analysis of the bovine genome revealed an expanded suite of β-defensin genes that encode what are referred to as antimicrobial or host defense peptides (HDPs). Whereas primate genomes also encode α- and θ-defensins, ... -
Bridging the gap – a new role for STAT3 in TLR4-mediated metabolic reprogramming
(2021)In this article, we discuss a new study from the laboratory of Ashley Mansell that successfully links innate immune receptor signaling to metabolic changes in macrophages, establishing for the first time an uninterrupted ... -
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
(American Society for Biochemistry and Molecular Biology, 2003)In this study we have identified members of the Toll-like receptor (TLR) family (namely, TLRs 4, 6, 8, and 9) as proteins to which the intracellular protein tyrosine kinase, Bruton's tyrosine kinase (Btk), binds. Detailed ... -
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS
(2005)Bruton's tyrosine kinase (Btk) has recently been shown to participate in the induction of nuclear factor ?B (NF?B)-dependent gene expression by the lipopolysaccharide (LPS) receptor Toll-like receptor-4 (TLR4). In this ... -
Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin
(2013)B cells signal through both the B cell receptor (BCR) which binds antigens and Toll-like receptors (TLRs) including TLR9 which recognises CpG DNA. Activation of TLR9 synergises with BCR signalling when the BCR and TLR9 ... -
Building unique bonds to fight misplaced DNA
(2013)A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the ... -
Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae
(2023)Tissue-resident memory CD4 T (TRM) cells induced by infection with Bordetella pertussis persist in respiratory tissues and confer long-term protective immunity against reinfection. However, it is not clear how they are ...