Browsing School of Biochemistry & Immunology by Title
Now showing items 293-312 of 1015
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Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages
(2016)Background: Particulate matter has been shown to stimulate the innate immune system and induce acute inflammation. Therefore, while nanotechnology has the potential to provide therapeutic formulations with improved efficacy, ... -
Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect
(British Pharmacological Society, 1987)Feverfew has been used since antiquity to treat inflammatory conditions. Extracts of the herb were found to inhibit mitogen-induced tritiated thymidine ([3H]-TdR) uptake by human peripheral blood mononuclear cells (PBMC), ... -
Factors affecting mitochondrial efficiency
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)Experiments were designed to investigate for the first time in situ synaptosomal mitochondrial bioenergetic function using synaptosomes prepared from the whole brain of rats and to compare bioenergetic functions in ... -
Factors influencing the induction of immune responses with DNA vaccines
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)Compared with any other medical discovery vaccines have prevented more deaths and suffering. Emergence of novel pathogens accentuates the requisite for ongoing development and improvement of traditional vaccination strategies. ... -
Facts and recommendations about total homocysteine determinations: an expert opinion
(American Association for Clinical Chemistry, 2004)Background: Measurement of plasma total homocysteine has become common as new methods have been introduced. A wide range of disorders are associated with increased concentrations of total homocysteine. The purpose of this ... -
Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells.
(2013)Apoptosis is commonly thought to represent an immunologically silent or even anti-inflammatory mode of cell death, resulting in cell clearance in the absence of explicit activation of the immune system. However, here ... -
Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis
(The American Society for Microbiology, 1999)Fasciolosis, like other helminth infections, is associated with the induction of T-cell responses polarized to the Th2 subtype. Respiratory infection with Bordetella pertussis or immunization with a pertussis whole-cell ... -
A fast, simple and robust protocol for growing crystals in the lipidic cubic phase
(2012)A simple and inexpensive protocol for producing crystals in the sticky and viscous mesophase used for membrane protein crystallization by the in meso method is described. It provides crystals that appear within 15–30 min ... -
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
(2014)Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition caused by mutations in the FLCN gene and characterized by benign hair follicle tumors, pneumothorax, and renal cancer. Folliculin (FLCN), the protein ... -
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.
(Elsevier, 2009)Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated ... -
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
(2021)Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic ... -
The function and regulation of IL-17A-producing T cell subsets in central nervous system autoimmunity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Multiple sclerosis (MS) is a chronic progressive autoimmune disease of the central nervous system (CNS). MS is characterised by the presence of demyelinating lesions in the CNS and is the leading cause of disability among ... -
Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226
(BioMed Central, 2006)BACKGROUND: Glycogen Synthase Kinase-3 (GSK3) activity is repressed following insulin treatment of cells. Pharmacological inhibition of GSK3 mimics the effect of insulin on Phosphoenolpyruvate Carboxykinase (PEPCK), ... -
Functional consequences of genetic polymorphism of the KIR3DL1/S1 receptor
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Natural Killer (NK) cells are crucial effector cells of the innate immune system that function to eliminate virally infected and transformed cells. The activation of these cells is controlled in part by the expression of ... -
Functional Group and Substructure Searching as a Tool in Metabolomics
(2008)Background: A direct link between the names and structures of compounds and the functional groups contained within them is important, not only because biochemists frequently rely on literature that uses a free-text format ... -
Functional Relevance of Interleukin 8 Haplotype for the Innate Immune System in Holstein-Friesian Cattle
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Calves rely heavily on their innate immune response in the post-birth period before their adaptive immune system develops. Interleukin 8 (IL-8) is a major chemoattractant predominantly associated with neutrophils response ... -
A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis
(2007)Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens1, 2, 3. The adaptor protein Mal (also known as TIRAP), encoded ...