Browsing School of Biochemistry & Immunology by Title
Now showing items 128-147 of 1015
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Ceramide activates NFkappaB by inducing the processing of p105
(The American Society for Biochemistry and Molecular Biology, 1998)The role of ceramide as a second messenger in tumor necrosis factor (TNF)-mediated signal transduction has been much debated. It is supported by recent reports describing an expanding number of potential targets for this ... -
Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1ß in delirium after hip fracture
(2014)Objective Exaggerated central nervous system (CNS) inflammatory responses to peripheral stressors may be implicated in delirium. This study hypothesised that the IL-1β family is involved in delirium, predicting increased ... -
Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue
(2014)Background Cathelicidins comprise a major group of host-defence peptides. Conserved across a wide range of species, they have several functions related to host defence. Only one cathelicidin has been found in humans but ... -
Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages.
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ... -
Characterisation of Membrane Glycoproteins that are Essential for Flagellar Attachment in the Bloodstream Form of Trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The African trypanosome, Trypanosoma brucei, is a unicellular parasitic protist that causes a severe disease, trypanosomiasis, in humans and livestock in sub-Saharan Africa. The trypanosome has a single flagellum that ... -
Characterisation of signalling pathways activated by the IL-1 receptor homologue T1/ST2
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2003)T1/ST2 is a member of the IL-1 receptor family possessing the three characteristic extracellular Ig domains and an intracellular Toll-IL1R (TIR) domain. It is an orphan receptor expressed on a variety of cell types including ... -
Characterisation of T cell responses during Staphylococcus aureus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)The development of anti-S. aureus vaccines has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. A comprehensive understanding of the discrete T cell subsets critical for ... -
Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called osteochondral defects (OCDs) can arise from ... -
Characterisation of the innate immune response to Campylobacter jejuni colonisation in the chicken intestine
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Campylobacter jejuni is the leading cause of gastroenteritis in humans, and chickens are the primary vector for infection. The microbe colonises the caeca of birds as a commensal, and it is hypothesised that intestinal ... -
Characterisation of the novel leucine rich repeat containing protein KIAA0644
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)This thesis reports the existence o f a novel leucine rich repeat containing protein annotated as KIAA0644 in the Kazusa DNA Research Institute database (www.Kazusa.or.jp). which was discovered in a study for proteins ... -
Characterisation of the role of Bruton's tyrosine kinase in toll-like receptor signalling
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Toll-like receptors (TLRs) are the primary surveillance system for the detection of pathogens and are crucial to the activation of the host innate response. TLRs contain an extracellular leucine rich repeat region which ... -
Characterization of CD44 induction by IL-1: a critical role for Egr-1
(The American Association of Immunologists, 1999)he adhesion molecule CD44 is a multifunctional, ubiquitously expressed glycoprotein that participates in the process of leukocyte recruitment to sites of inflammation and to their migration through lymphatic tissues. In ... -
Characterization of Staphylococcal protein A cellular interactions to facilitate its development as a vaccine antigen
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The development of a vaccine from bench to bedside is a lengthy and complex process, which is so rarely fully realized and followed throughout. During the course of this project, we have been able to follow the development ... -
Characterization of two protein disulphide iosmerases from the endocytic pathway of Trypanosoma brucei
(American Society for Biochemistry and Molecular Biology, 2005)Proteins from the endocytic pathway in bloodstream forms of Trypanosome brucei are modified by the addition of linear poly-N-acetyllactosamine side chains, which permits their isolation by tomato lectin affinity chromatography. ... -
Characterizing caspase-1 involvement during esophageal disease progression.
(2020)Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ... -
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression
(2004)Suppressors of cytokine signaling (SOCS) are encoded by immediate early genes known to inhibit cytokine responses in a classical feedback loop. SOCS gene expression has been shown to be induced by many cytokines, ... -
Chitin-derived STING Activators as Adjuvants and Therapeutics
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)A significant challenge in the advancement of vaccine research is a lack of adjuvants that can safely drive potent cellular immunity against intracellular pathogens and cancer, a problem only exacerbated by our limited ... -
Chitosan based adjuvants promote proinflammatory Th1 and Th17 responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Particulate vaccine adjuvants, including alum and biodegradable polymer microparticles, are strong activators of antigen-specific humoral immunity. These particulates enhance NLRP3 inflammasome activation, but they are ... -
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future
(2022)A plethora of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic tests are available, each with different performance specifications, detection methods, and targets. This narrative review aims to ...