Browsing Mechanical & Manufacturing Eng (Theses and Dissertations) by Subject "Bone"
Now showing items 1-4 of 4
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Biophysical Regulation of Stem Cell Osteogenic Lineage Commitment: A Role for the Cytoskeleton
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is a debilitating disease characterised by weakened bone architecture due to increased resorption activity of osteoclasts and diminished bone deposition by mesenchymal stem cell (MSC) derived osteoblasts. ... -
Developing Microphysiological Systems of Bone Development, Physiology, and Repair
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Accurate models of human tissues and organ systems are foundational in our efforts to better understand human physiology. In the context of bone, a number of in vitro and in vivo models have been developed that facilitate ... -
The Development of a Novel 3D Bioprinting Strategy to Drive Vascularisation, and its Application for Bone Tissue Engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the major challenges facing the field of tissue engineering today is vascularisation. Without a system in place to circulate oxygen, nutrients and metabolites, the size of many tissue engineered constructs is ... -
Integrating non-viral gene therapy and 3D bioprinting for bone, cartilage and osteochondral tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)The repair of osteochondral defects, affecting both the articular cartilage and the underlying subchondral bone, is key for the effective recovery of joint homeostasis and the prevention of further cartilage degeneration ...