Browsing Mechanical & Manufacturing Eng (Theses and Dissertations) by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-12 of 12
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3D Bioprinted Cartilaginous Templates as Developmentally Inspired Implants for Large Bone Defect Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Whilst bone possesses an inherent capacity for regeneration, defects above a critical size cannot heal on their own. Damaged or diseased bone can be treated using autografts or a range of different bone grafting biomaterials, ... -
3D Bioprinting of Developmentally Inspired Templates for Bone and Joint Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)There is an urgent need to develop alternatives to synthetic joint prosthesis to promote the regeneration of diseased osteoarthritic joints. Cell based therapies have shown promise for repairing cartilage and bone; however, ... -
Adaptive Liquid Cooling Methods in Microchannel Heat Sinks
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)This work investigates the effect of implementing three varying cooling techniques for high heat flux electronics cooling. High heat fluxes are being experienced in data centres as the number of transistors per inch increases ... -
Applying thermal post-processing techniques to engineer the microstructure and mechanical performanceof selective-laser-melted Ti-6Al-4V ELI
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)As an additive manufacturing technology, selective laser melting (SLM) affords the creation of customisable parts at high resolutions to within the micron range. Among the materials being processed by SLM systems, the ... -
Developing Microphysiological Systems of Bone Development, Physiology, and Repair
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Accurate models of human tissues and organ systems are foundational in our efforts to better understand human physiology. In the context of bone, a number of in vitro and in vivo models have been developed that facilitate ... -
Development and Functional Assessment of a Decellularised Injectable Biomaterial Combined with Nasal Chondrocytes for Intervertebral Disc Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Lower Back Pain (LBP) is known to be a major health issue worldwide with a significant socioeconomic impact and it is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD). IVD degeneration ... -
Development of mechanobiomimetic strategies to drive stem cell behaviour for bone regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)There are a host of cases where clinical intervention must be taken to treat diseased or damaged bone, including severe fractures, defects, tumours requiring tissue removal, and debilitating diseases such as osteoporosis. ... -
Fundamental Insights into Arterial Remodelling; Strain-Mediated Degradation of Arterial Collagen
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Maladaptive remodelling of structurally significant collagen fibres in the arterial wall is believed to play a critical role in the development and progression of degenerative arterial disease. A greater understanding of ... -
Multipotent vascular stem cells and the effects of cyclic tensile strain, collagen structure and stenting on medial vascular cell populations
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Atherosclerosis is one of the leading causes of mortality worldwide, and presents as a narrowing or occlusion of an artery. Interventions to re-open the arterial lumen can result in re-occlusion through intimal hyperplasia. ... -
On effect of primed cellular microcapsules and pH neutralizing biomaterials to augment regeneration of the intervertebral disc
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the most common topics of research worldwide for medical health care is low back pain (LBP). It is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD), the shock absorbent soft ... -
Proxy measurement and strategic metering methodologies for resource transparency of industrial systems
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)For the latest advancement of manufacturing systems, namely Industry 4.0 or Smart Manufacturing, large amounts of precise process data are required. However, the acquisition of sufficient data represents a challenge for ... -
Unravelling the role of mechanical cues on the chondrogenic differentiation of stem cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)The inability of adult articular cartilage to regenerate has motivated the development of tissue engineering strategies to repair cartilage defects before they progress to osteoarthritis. Common cell based strategies ...