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Now showing items 21-40 of 188

  • An improved framework for the inverse analysis of skeletal muscle tissue in-vivo 

    Moerman, Kevin Mattheus (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)
    This thesis focusses on the development of an experimental and computational framework for the non-invasive analysis of the passive mechanical properties of living human skeletal muscle tissue. This is relevant to many ...
  • An investigation into the causes of higher rates of restenosis in peripheral arteries compared with coronary arteries following stenting 

    Early, Michael (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2010)
    The use of stenting in peripheral arteries has been limited by rates of in-stent restenosis and stent fracture considerably higher than seen in coronary arteries. Traditional balloon expandable stainless steel stents were ...
  • An investigation into the influence of cardiovascular stent design on the development of restenosis using the finite element method 

    Lally, Caitriona (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)
    Finite element models, which can determine the degree of vascular injury caused to a vessel by a stent and hence ascertain the propensity of that stent design to cause in¬stent restenosis, would be a valuable tool for both ...
  • An investigation into the role of substrate stiffness and oxygen availability in the regulation of stem cell differentiation during tissue regeneration 

    Burke, Darren Paul (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)
    Mesenchymal stem cells (MSCs) are multipotent cells which can differentiate down multiple lineages and potentially generate tissues such as cartilage, bone or adipose tissue. It is becoming increasingly clear that mechanical ...
  • An investigation of joint tissue derived stem cells for articular cartilage tissue engineering 

    Vinardell, Tatiana (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    Tissue engineering has emerged as a promising approach to repair damaged articular cartilage. The associated drawbacks with the isolation and expansion of chondrocytes from autologous tissue have prompted significant ...
  • An investigation of structure-function relations in articular cartilage during skeletal maturation 

    Gannon, Alanna (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)
    The over-riding objective of this thesis was to build upon our current understanding of the evolving nature of articular cartilage mechanics by elucidating how changes to structure and composition of the tissue during ...
  • An optimized surface topography for calcium phosphate bone tissue engineering scaffolds 

    Mealy, Jacob Sebastian (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)
    Improved scaffold/host integration and avoiding core necrosis are important and active goals in tissue engineering. Alternatives to bone tissue grafting that are highly bioactive and inexpensive to manufacture are clinical ...
  • Analysis of noise source mechanisms for a subsonic jet 

    Power, Orla (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)
    Despite advances in engine design, from high bypass to co-axial or lobe shaped nozzles, the problem of jet noise reduction continues to require ongoing research in order to comply with the criteria inherent in environmental ...
  • Analysis of the elastic and inelastic behaviour of healthy and diseased arterial tissue 

    Maher, Eoghan (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)
    Mechanical factors play a key role in determining the success of clinical procedures such as balloon angioplasty and stenting that aim to increase lumen size in atherosclerotic lesions. Finite element modelling is commonly ...
  • Aspects of the fatigue behaviour of acrylic bone cement 

    Murphy, Bruce Philip (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2002)
    Polymethylmethacrylate bone cement is used to fixate many orthopaedic implants. However, it is a brittle material, prone to damage accumulation leading to cement cracking and prosthesis loosening. The damage accumulation ...
  • BIOFABRICATION STRATEGIES TO GUIDE THE SELF-ORGANISATION OF BIOMIMETIC CARTILAGE AND OSTEOCHONDRAL TISSUES 

    Burdis, Ross (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)
    The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at least in part, to a failure to recapitulate the structure, composition and functional properties of the target tissue. This has ...
  • A Biomechanical Assessment of Direct and Inertial Head Loading in Rugby Union 

    TIERNEY, GREGORY JOHN (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)
    Rugby union is a territorial, dynamic and high-impact collision sport. Unfortunately, due to its physical and high impact nature, the incidence of concussion is high. There is mounting evidence that repeatedly sustaining ...
  • Biomechanical origins of osteoporosis 

    McNamara, Laoise Maria (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)
    The contention of this thesis is that a pathological change in bone tissue material properties during osteoporosis ahers the mechanical stimuli to bone remodelling cells and drives them to adapt the trabecular architecture ...
  • Biomechanics of Repair in Invertebrates 

    O'NEILL, MAEVE (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)
    Repair is a ubiquitous process in nature, and it is one of the many features of biological materials that humans are constantly attempting to recreate. Though the process of repair has been studied in mammals, very little ...
  • Biophysical Regulation of Stem Cell Osteogenic Lineage Commitment: A Role for the Cytoskeleton 

    STAVENSCHI, ELENA (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)
    Osteoporosis is a debilitating disease characterised by weakened bone architecture due to increased resorption activity of osteoclasts and diminished bone deposition by mesenchymal stem cell (MSC) derived osteoblasts. ...
  • Boundary element methods for the prediction of aircraft noise shielding in flight 

    Clancy, Cathal (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    Aircraft noise emissions may be significantly reduced by positioning the aeroengines above the wings or fuselage so as to utilize the shielding effect of the airframe. Computational tools are likely to play a key role in ...
  • Bubble growth dynamics in nucleate pool boiling with liquid subcooling effects 

    Mat Nawi, Muhad Rozi (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    Heat transfer in nucleate pool boiling has been characterized by very high dissipated heat fluxes whilst requiring low driving temperature differences. The rate of bubble growth and the subsequent bubble motion has a ...
  • Bubble growth dynamics including gravitational and electric field effects 

    Di Bari, Sergio (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    In the present work the hydrodynamics of adiabatic gas bubble growth from a submerged orifice is investigated with the view of elucidating the interdependence of the bubble shape and the pressure field during growth and ...
  • Bubble impingement and the mechanisms of heat transfer enhancement 

    Donoghue, David B (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    Fluid agitation and mixing ensuing from two phase flow has an important role to play within two phase flow heat exchangers, which are at the forefront of energy conversion. Within these environments, vapour bubbles may ...
  • Bubble-induced Marangoni convection 

    O'Shaughnessy, Séamus (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    Thermal Marangoni convection about a 1mm radius air bubble situated under a heated wall of constant temperature immersed in a silicone oil layer (Pr = 220) of constant depth 5mm was experimentally investigated using a flow ...