Sort by: Order: Results:

Now showing items 170-189 of 198

  • The development of an active implantable neural probe system for chronic use 

    Frey, Laura Constance (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)
    The alleviation of symptoms of debilitating neural conditions via neural probes is an increasingly important area of research. However, the effectiveness of these probes decreases over time due to the formation of a glial ...
  • The effect of bone turnover on bone quality and material properties 

    Kennedy, Oran D. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2008)
    Coined in French in the 1820s as a description of a pathological state of bone tissue, the term osteoporosis made its way into the English language only in the 20th century. Unlike other medical concepts, which have not ...
  • The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold 

    McMahon, Louise Ann (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)
    Adult mesenchymal stem cells (MSCs) offer great potential in tissue engineering applications as they can be directed to differentiate along numerous lineages to produce a range of skeletal tissues, including the chondrogenic ...
  • The effect of mechanical cues on the chondrogenic differentiation of bone marrow derived mesenchymal stem cells 

    Thorpe, Stephen (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)
    Tissue engineering strategies utilising mesenchymal stem cells (MSCs) represent a promising treatment option for a range of injuries and diseases. If MSCs are to be implanted in vivo, understanding the intricacies of how ...
  • The effect of stress concentrations on fatigue and fracture of 316L stainless steel micro-scale components 

    Wiersma, Susanne Amanda (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)
    The aim of this work was to investigate the fatigue and fracture behaviour of microscopic specimens based on a biomedical component (the cardiovascular stent) and to modify existing theories to take account of the observed ...
  • The effects of a sliding air bubble on heat transfer from an inclined surface 

    Donnelly, Brian (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)
    An investigation into the effect of a single sliding air bubble on heat transfer from a submerged, inclined surface has been performed. It is known that bubbles, both vapour and gas, can increase heat transfer rates from ...
  • The evolution of an impinging synthetic air jet 

    Farrelly, Rayhaan (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)
    Impinging synthetic jets are considered to offer great potential for many applications, including the thermal management of electronics. In this study, an experimental investigation into the evolution of an impinging ...
  • The fatigue behaviour of three-dimensional stress concentrations 

    Bellett, Daniel (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2003)
    The fatigue behaviour of complex three-dimensional notched components is a subject of great practical interest to industrial engineers. Unfortunately, the analysis of this type of feature presents problems for most assessment ...
  • The influence of chevrons on the turbulent characteristics of jets 

    Kennedy, John (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2010)
    To minimize the significant environmental impact of air travel a reduction in noise pollution from jet engines is required. This has led to a renewed focus on active and passive techniques which modify the turbulence ...
  • The influence of scoliosis and wheechair customisations in rear impact 

    Walsh, Jennifer C. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)
    Considerable advances in wheelchair occupant frontal impact safety have been achieved, but further research in rear impact is required. Future analysis would benefit from more biofidelic representation of wheelchair ...
  • The mechanics of wound closure for laparoscopic surgery 

    Lyons, Mathew (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    The increase in popularity of laparoscopic surgery over the past 25 years has led to a greater importance of reducing the incidence of complications associated with the surgery. Development of a hernia at a trocar port ...
  • The relationship between blood perfusion and thermal measurements at the skin surface 

    Nicholson, Christopher P. B. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)
    Blood perfusion is defined as the volumetric flow rate of blood through a given volume of tissue. Blood perfusion measurements are an important clinical indicator for many medical conditions but to date there is no cost ...
  • The relationship between micro-structure and mechanical behaviour in passive skeletal muscle 

    Takaza, Michael (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    This thesis presents and discusses investigative work performed on characterising the behavioural response of skeletal muscle tissue that was subjected to large deformations. The passive mechanical properties of muscle ...
  • THEREPI: A therapeutic epicardial reservoir for the treatment of cardiac disease 

    WHYTE, WILLIAM (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)
    The clinical translation of regenerative therapy for the diseased heart, whether in the form of cells, macromolecules or small molecules, is hampered by several factors: the poor retention and short biological half-life ...
  • Thermal aspects of the grinding process 

    Walsh, Darren Gerard (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2000)
    Grinding is a commonly used process for material removal. It has been used for a long time mainly as a finishing process, although this situation is changing, with the development of creep feed grinding, and high efficiency ...
  • Three-dimensional vortex particle-in-cell technique 

    Cox, Damien (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)
  • Time domain calculation of noise generated by a propeller in a flow 

    Carley, Michael (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 1997)
    In this thesis, the problem of calcultaing the noise from an acoustically subsonic aircraft propeller is approached using a "moving medium" method. An established theory of noise generation by rigid bodies in motion is ...
  • Time-resolved noise source analysis in subsonic turbulent jets 

    Breakey, David E. S. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
  • Tissue engineering scaled-up anatomically shaped osteochondral constructs for joint resurfacing 

    Mesallati, Tariq (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)
    Partial and total joint replacements are the only surgical procedures currently available to treat articular cartilage degeneration associated with degenerative diseases such as osteoarthritis (OA). While these procedures ...
  • Towards 3D bioprinting of anatomically accurate, mechanically reinforced cartilage templates for biological joint resurfacing 

    CRITCHLEY, SUSAN (Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)
    Osteoarthritis (OA) is a pervasive disease worldwide which affects the articular cartilage and the underlying bone in synovial joints such as the knee. Currently, the only treatment for a severely degenerated knee joint ...