Browsing Dental Science (Scholarly Publications) by Sponsor "Science Foundation Ireland (SFI)"
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COMPARATIVE GENOMICS AND THE EVOLUTION OF PATHOGENICITY IN HUMAN PATHOGENIC FUNGI
(2011)Because most fungi have evolved to be free-living in the environment and because the infections they cause are usually opportunistic in nature, it is often difficult to identify specific traits that contribute to fungal ... -
Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in ¿-, ß- and ¿- TLO gene function.
(2023)The Candida albicans genome contains between ten and fifteen distinct TLO genes that all encode a Med2 subunit of Mediator. In order to investigate the biological role of Med2/Tlo in C. albicans we deleted all fourteen TLO ... -
The importance of repulsive potential barriers for the dispersion of graphene using surfactants
(2010)We have dispersed graphene in water, stabilized by a range of 12 ionic and non-ionic surfactants. In all cases, the degree of exfoliation, as characterized by flake length and thickness, was similar. The dispersed flakes ... -
Telomeric ORFs (TLOs) in Candida spp. encode Mediator subunits that regulate distinct virulence traits
(2014)The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C. albicans ... -
Telomeric ORFS in Candida albicans : Does Mediator Tail Wag the Yeast?
(2015)Recent studies of fungal genomes have shown that subtelomeric regions of chromosomes are areas of rapid evolution that facilitate adaptation to novel niches [1]. Several years ago, analysis of the genome of the human ... -
Transcript profiling reveals rewiring of iron assimilation gene expression in Candida albicans and C. dubliniensis
(2012)Hyphal growth is repressed in Candida albicans and C. dubliniensis by the transcription factor Nrg1. Transcript profiling of a C. dubliniensis NRG1 mutant identified a common group of 28 NRG1 repressed genes in both species, ...