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  • Evidence against a role for NLRP3-driven islet inflammation in db/db mice 

    O'Neill, Luke; Kammoun, H.L.; Allen, T.L.; Henstridge, D.C.; Barre, S.; Coll, R.C.; Lancaster, G.I.; Cron, L.; Reibe, S.; Chan, J.Y.; Bensellam, M.; Laybutt, D.R.; Butler, M.S.; Robertson, A.A.B.; Cooper, M.A.; Febbraio, M.A. (2018)
    Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure ...