Browsing Biochemistry (Scholarly Publications) by Author "O'FARRELLY, CLIONA"
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Absence of oats toxicity in adult coeliac disease.
O'FARRELLY, CLIONA (1996) -
Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylceramide
O'FARRELLY, CLIONA; O'REILLY, VINCENT; Dunne, Margaret; AMU, SYLVIE; FALLON, PADRAIC; DOHERTY, DEREK; ZENG, SHIJUAN GRACE (2011)Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid ?-galactosylceramide (?-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. ... -
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production.
O'FARRELLY, CLIONA; LYNCH, LYDIA (2012)Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that influence inflammatory responses. We have shown that iNKT cells, previously thought to be rare in humans, were highly enriched in ... -
Alpha gliadin antibody levels: a serological test for coeliac disease.
O'FARRELLY, CLIONA (1983)The diagnostic value in coeliac disease of circulating antibodies to casein, crude gliadin, and alpha gliadin was assessed using an adaption of the enzyme linked immunosorbent assay system. alpha Gliadin was the only antigen ... -
Altered gastrointestinal immune response in sarcoidosis.
O'FARRELLY, CLIONA (1988)Because of the possible clinical association between coeliac disease and sarcoidosis, the incidence of humoral sensitivity to dietary proteins was examined in patients with sarcoidosis. Raised concentrations of circulating ... -
Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.
MORRIS, DEREK; O'FARRELLY, CLIONA; BRADLEY, DANIEL; KENNY, ELAINE (2012)Campylobacter jejuni is the most common cause of human bacterial gastroenteritis and is associated with several post-infectious manifestations, including onset of the autoimmune neuropathy Guillain-Barre syndrome, causing ... -
Bovine b946;-defensin gene family: Opportunities to improve animal health?
O'FARRELLY, CLIONA (2014)Recent analysis of the bovine genome revealed an expanded suite of β-defensin genes that encode what are referred to as antimicrobial or host defense peptides (HDPs). Whereas primate genomes also encode α- and θ-defensins, ... -
The CD4 + T cell methylome contributes to a distinct CD4 + T cell transcriptional signature in Mycobacterium bovis-infected cattle
O'FARRELLY, CLIONA (2016)We hypothesised that epigenetic regulation of CD4+ T lymphocytes contributes to a shift toward a dysfunctional T cell phenotype which may impact on their ability to clear mycobacterial infection. Combined RNA-seq transcriptomic ... -
Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?
O'FARRELLY, CLIONA; LYNCH, LYDIA (2007)BACKGROUND: Uterine lymphoid cell repertoires are specialized in order to meet the twin demands of successful pregnancy and local immunosurveillance. The possibility that some of these populations might differentiate ... -
Cellular response to alpha-gliadin in untreated coeliac disease.
O'FARRELLY, CLIONA (1982)An improved technique for the detection of alpha-gliadin sensitised mononuclear cells in the peripheral blood of untreated coeliac patients is described. This method is a modification of the direct LMIF assay, and involves ... -
Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue
O'FARRELLY, CLIONA (2014)Background Cathelicidins comprise a major group of host-defence peptides. Conserved across a wide range of species, they have several functions related to host defence. Only one cathelicidin has been found in humans but ... -
Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships
O'FARRELLY, CLIONA; LYNCH, LYDIA (2010)Anxiety confers increased risk for inflammatory diseases, and elevated inflammatory activity in anxious individuals may contribute to this increased risk. One complication, however, is that anxiety could be associated with ... -
Comparative genomic identification and validation of ??-defensin genes in the Ovis aries genome
O'FARRELLY, CLIONA (2017) -
Differential antimicrobial peptide gene expression patterns during early chicken embryological development
O'FARRELLY, CLIONA; LLOYD, ANDREW THOMAS (2009)The adaptive immune system is not completely developed when chickens hatch, so the innate immune system has evolved a range of mechanisms to deal with early pathogenic assault. Avian b-defensins (AvBDs) and cathelicidins ... -
Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells.
O'FARRELLY, CLIONA; DOHERTY, DEREK (2002)Background: Small intestinal epithelial cells (SIEC) may contribute to local immune regulation. Aim: To examine production of interleukin (IL)-1α , IL-1β and IL-6 by freshly isolated human SIEC. Methods: IL-1α and ... -
Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease
O'FARRELLY, CLIONA (2011)Objective: TNF inhibitors (TNFi) have revolutionised the treatment of rheumatoid arthritis (RA). Natural killer (NK) cells and Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose ... -
Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes.
KELLEHER, DERMOT P; O'FARRELLY, CLIONA (Taylor and Francis, 1995)Bromodeoxyuridine incorporation is a useful method for studying the pattern of DNA synthesis in proliferating cells. The distribution pattern of incorporated BrdU in villus enterocytes of duodenal explants was analysed ... -
The effects of tumour necrosis factor-alpha and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis.
O'FARRELLY, CLIONA (2006)OBJECTIVE: Cytokines are likely to play a key pathogenic role in thyroid-associated ophthalmopathy (TAO). Anti-cytokine therapy has been proposed to be a possible treatment for active TAO. We aimed to establish the ... -
Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration.
O'FARRELLY, CLIONA (1998)