Browsing Biochemistry (Scholarly Publications) by Author "LYNCH, MARINA"
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Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells
MILLS, KINGSTON; MCQUILLAN, KEITH; LYNCH, MARINA (2010)Microglia are innate immune cells of the CNS, that act as antigen-presenting cells (APC) for antigen-specific T cells and respond to inflammatory stimuli, such as amyloid-beta (A?), resulting in the release of neurotoxic ... -
Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
MILLS, KINGSTON; LYNCH, MARINA; LALOR, STEPHEN (2010)Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis, where disease is mediated by autoantigen-specific T cells. Although there is evidence linking CD4+ T cells that secrete IL-17, termed ... -
Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages.
MILLS, KINGSTON; DUNGAN, LEONORA; LYNCH, MARINA (2014)The role of IFN-γ in the pathogenesis of autoimmune diseases is controversial. Although Th1 cells can induce experimental autoimmune encephalomyelitis (EAE), IFN-γ can suppress Th17 cells that are pathogenic in EAE. Here ... -
Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines
LAVELLE, EDWARD; MILLS, KINGSTON; LYNCH, MARINA; ARMSTRONG, MICHELLE (2005)Intranasal delivery of vaccines provides an attractive alternative to parenteral delivery, but it requires appropriate mucosal adjuvants. Cholera toxin (CT) is a powerful mucosal adjuvant, but it can undergo retrograde ...