Browsing Biochemistry (Scholarly Publications) by Author "LALOR, STEPHEN"
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Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
MILLS, KINGSTON; LYNCH, MARINA; LALOR, STEPHEN (2010)Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis, where disease is mediated by autoantigen-specific T cells. Although there is evidence linking CD4+ T cells that secrete IL-17, termed ... -
Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease.
LAVELLE, EDWARD; MILLS, KINGSTON; LALOR, STEPHEN (2009)IL-17 producing CD4+ T (Th17) cells are pathogenic in many autoimmune diseases. The induction and expansion of Th17 cells is directed by cytokines, including IL-23 and IL-1?, produced by innate immune cells through ... -
Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.
LAVELLE, EDWARD; MILLS, KINGSTON; LALOR, STEPHEN (2009)Th17 cells, CD4(+) T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and expansion is driven by the cytokines IL-6, TGF-beta, IL-21, IL-1, and IL-23. However, there ... -
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
GEOGHEGAN, JOAN; ROGERS, THOMAS; MAC AOG?IN, MICHE?L; MCLOUGHLIN, RACHEL; LAVELLE, EDWARD; FOSTER, TIMOTHY; FENNELL, JEROME; LALOR, STEPHEN (2015)Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using ... -
The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen.
GEOGHEGAN, JOAN; MCLOUGHLIN, RACHEL; LALOR, STEPHEN (2017) -
Staphylococcus aureus Infection of Mice Expands a Population of Memory gamma delta T Cells That Are Protective against Subsequent Infection
MILLS, KINGSTON; MCLOUGHLIN, RACHEL; LALOR, STEPHEN (2014)