Browsing Biochemistry (Scholarly Publications) by Author "FINLAY, DAVID"
Now showing items 1-14 of 14
- Sort by:
- title
- issue date
- submit date
- Order:
- ascending
- descending
- Results:
- 5
- 10
- 20
- 40
- 60
- 80
- 100
-
Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.
FINLAY, DAVID (2014)The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK). However, the ... -
AMPKα1: A glucose sensor that controls CD8 T-cell memory.
FINLAY, DAVID (2013) -
Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3
FINLAY, DAVID (PubMed Central, 2005)GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. Inhibition of GSK3 in animal models of diabetes leads to normalization of blood glucose levels, ... -
Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226
FINLAY, DAVID (BioMed Central, 2006)BACKGROUND: Glycogen Synthase Kinase-3 (GSK3) activity is repressed following insulin treatment of cells. Pharmacological inhibition of GSK3 mimics the effect of insulin on Phosphoenolpyruvate Carboxykinase (PEPCK), ... -
LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells
FINLAY, DAVID (Wiley-Blackwell, 2010)The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the ... -
MTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function
FINLAY, DAVID; WALTON, CLAIR (2014)The mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cellular metabolism and also has fundamental roles in controlling immune responses. Emerging evidence suggests that these two functions of mTORC1 ... -
Notch-induced T cell development requires phosphoinositide-dependent kinase 1
FINLAY, DAVID (PubMed Central, 2007)Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for ... -
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
FINLAY, DAVID (Nature, 2008)Phosphatidylinositol-3-OH kinase (PI(3)K) and the nutrient sensor mTOR are evolutionarily conserved regulators of cell metabolism. Here we show that PI(3)K and mTOR determined the repertoire of adhesion and chemokine ... -
Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation
FINLAY, DAVID (American Society for Microbiology, 2009)The present study explored the consequences of phosphoinositide (3,4,5)-triphosphate [PI(3,4,5)P(3)] binding to the pleckstrin homology (PH) domain of the serine/threonine kinase 3-phosphoinositide-dependent kinase 1 (PDK1). ... -
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
FINLAY, DAVID (2011)In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this ... -
Regulation of glucose metabolism in T cells: new insight into the role of phosphoinositide 3-kinases
FINLAY, DAVID (2012)Naïve T cells are relatively quiescent cells that only require energy to prevent atrophy and for survival and migration. However, in response to developmental or extrinsic cues T cells can engage in rapid growth and robust ... -
Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections
FINLAY, DAVID (2017) -
T cell receptor signaing controls Foxp3 expression via PI3K, Akt and mTOR.
FINLAY, DAVID (National Academy of Sciences, 2008)Regulatory T (Treg) cells safeguard against autoimmunity and immune pathology. Because determinants of the Treg cell fate are not completely understood, we have delineated signaling events that control the de novo expression ... -
What Fuels Natural Killers? Metabolism and NK Cell Responses
FINLAY, DAVID; GARDINER, CLAIR (2017)