Browsing Biochemistry (Scholarly Publications) by Author "Brindisi, Margherita"

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  • A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 

    Zisterer, Daniela; Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania (2018)
    We developed a Jocic-type protocol for the construction of the pyrrolonaphthoxazepine (PNOX) core. After an initial investigation based on the isolation of a trichloromethyl carbinol derivative, we shifted our attention ...

  • Raising the bar in anticancer therapy:recent advances in, and perspectives on, telomerase inhibitors 

    Zisterer, Daniela; Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe (2019)
    Telomerase is a ribonucleic reverse transcriptase enzyme that uses an integral RNA component as a template to add tandem telomeric DNA repeats, TTAGGG, at the 3′ end of the chromosomes. 85–90% of human tumors and their ...

  • Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 

    Zisterer, Daniela; O'Sullivan, Jeffrey; Brindisi, Margherita; Ulivieri, Cristina; Alfano, Gloria; Gemma, Sandra; de Asís Balaguer, Francisco; Khan, Tuhina; Grillo, Alessandro; Chemi, Giulia; Menchon, Grégory; Prota, Andrea E.; Olieric, Natacha; Lucena-Agell, Daniel; Barasoain, Isabel; Fernando Diaz, J.; Nebbioso, Angela; Conte, Mariarosaria; Lopresti, Ludovica; Magnano, Stefania; Amet, Rebecca; Kinsella, Paula; Ibrahim, Ola; Morbidelli, Lucia; Spaccapelo, Roberta; Baldari, Cosima; Butini, Stefania; Novellino, Ettore; Campiani, Giuseppe; Altucci, Lucia; Steinmetz, Michel O.; Brogi, Simone (2019)
    Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. ...