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  • TRAM is required for TLR2 endosomal signaling to type I IFN induction 

    Bowie, Andrew; Mc Loughlin, Rachel (2014)
    Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type I ...