Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 21-40 of 724
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Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production.
(2012)Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that influence inflammatory responses. We have shown that iNKT cells, previously thought to be rare in humans, were highly enriched in ... -
Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.
(Springer, 2017)Interferon-alpha (IFN-a) is a potent anti-viral cytokine, critical to the host immune response against viruses. IFN-a is first produced upon viral detection by pathogen recognition receptors. Following its expression, IFN-a ... -
Advances in immunotherapy for the treatment of glioblastoma.
(2017)Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, ... -
Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
(2019)Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of ... -
Alpha gliadin antibody levels: a serological test for coeliac disease.
(1983)The diagnostic value in coeliac disease of circulating antibodies to casein, crude gliadin, and alpha gliadin was assessed using an adaption of the enzyme linked immunosorbent assay system. alpha Gliadin was the only antigen ... -
Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines
(2019)Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3–4 million cases globally with 100,000–150,000 deaths reported annually. Mostly confined to developing nations, ... -
Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential.
(2015)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has ... -
Altered gastrointestinal immune response in sarcoidosis.
(1988)Because of the possible clinical association between coeliac disease and sarcoidosis, the incidence of humoral sensitivity to dietary proteins was examined in patients with sarcoidosis. Raised concentrations of circulating ... -
Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis.
(2018)Rheumatoid arthritis is characterized by synovial proliferation, neovascularization and leucocyte extravasation leading to joint destruction and functional disability. The blood vessels in the inflamed synovium are highly ... -
Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells
(2013)Alveolar macrophages (AMs) from mice and humans have long been known to contribute to maintaining tolerance in the lung. Studies have shown that AMs can induce anergy in CD4+ T cells. Nitric oxide, prostaglandins, and ... -
Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3
(PubMed Central, 2005)GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. Inhibition of GSK3 in animal models of diabetes leads to normalization of blood glucose levels, ... -
Anti-inflammatory actions of a taurine analogue; ethane ?-sultam; in phagocytic cells; in vivo and in vitro
(Elsevier, 2011)The ability of a taurine prodrug, ethane ?-sultam, to reduce cellular inflammation has been investigated, in vitro, in primary cultures of alveolar macrophages and an immortilised N9 microglial cell line and in vivo in an ... -
Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
(American Association for the Advancement of Science, 2005)Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a membrane-addressing ... -
The Appearance of escape variants in vivo does not account for the failure of recombinant envelope vaccines to protect against simian immunodeficiency virus
(Society for General Microbiology, 1999)The presence or evolution of immune escape variants has been proposed to account for the failure of recombinant envelope vaccines to protect macaques against challenge with simian immunodeficiency virus (SIVmac). To address ... -
Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
(2019)Astrocytes are the most numerous cell type in the brain and perform several essential functions in supporting neuronal metabolism and actively participating in neural circuit and behavioral function. They also have ...